Biological and Antioxidant Activities of the Ethanol Extract of Natural Sources and its Nanoparticles from Red tea, Green tea, Roselle, Fenugreek and Ginger | ||
| Arab Journal of Biotechnology | ||
| Volume 24, Issue 1, June 2025, Pages 1-17 PDF (1.2 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/arjb.2025.366508.1001 | ||
| Authors | ||
| Eman A Hanafy* 1; Emad Shalaby2; Ahmed A Salah El-din1; Nermin E Mohamed1; Nadeen S Bahlol1 | ||
| 1Cairo university | ||
| 2Department of Biochemistry, Faculty of Agriculture, Cairo University | ||
| Abstract | ||
| Purpose: Nano biotechnology has huge potential in a variety of biological sciences. It involves using particles smaller than 100 nm in size. Due to the disadvantages of chemical nanoparticle synthesis, there is an increasing demand for green nanoparticle synthesis. In particular, AgNPs are essential to nanomedicine and other fields of nanoscience and nanotechnology. While many noble metals have been applied for a variety of uses, AgNPs have received particular attention due to their potential for use in the treatment and diagnostics of cancer. Methods: The current research indicates that green biosynthesis of AgNPs using five different plant ethanol extracts (red tea, green tea, roselle, fenugreek, and ginger) is the best approach for producing metal nanoparticles in order to avoid using toxic and high-energy physical and chemical processes. Determination of phenolics, flavonoids, and catechins was performed, and UV–visible spectroscopy, zeta potential, and FTIR were analyzed. In addition, the antioxidant activity against DPPH, ABTS, and KMnO4 was evaluated. As well, the cytotoxicity of ginger nanoparticles is tested against HepG2 cell lines. Results: According to the results, ginger AgNPs has a significant antioxidant capacity that exceeds that of ascorbic acid (against DPPH and KMnO4 assays) and moderate toxicity to HepG2, with an IC50 of 424.62 μg/mL. Conclusion: Green chemistry is important in many areas, including health, where we discovered that plant-based nanoparticles are very antioxidant-rich and have strong antioxidant and anti-cancer properties. | ||
| Keywords | ||
| Red tea; Green tea; Roselle; Fenugreek; Ginger | ||
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