Serum Concentration of Osteopontin and Interleukin 17 in Psoriatic Patients and Their Relation to Disease Severity | ||
| Egyptian Journal of Medical Microbiology | ||
| Volume 34, Issue 3, July 2025, Pages 509-515 PDF (307.68 K) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.379547.1595 | ||
| Authors | ||
| Zeinab Khaled* 1; Samia M. Elsaied1; Nessma A. Nosser2; Fatma F. El Dakrory1 | ||
| 1Department of Dermatology, Andrology& STDs, Faculty of Medicine, Mansoura University, Egypt | ||
| 2Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt | ||
| Abstract | ||
| Background: The pathogenesis of psoriasis vulgaris (PV) appears to be mediated by the interplay between immune cells, and keratinocytes. Osteopontin (OPN) also engaged in the pathogenesis of psoriasis. Objective: To assess the level of OPN and IL-17 in the serum of psoriatic cases and compare it with their level in healthy people. Methodology: This case control study was conducted on 50 cases with chronic plaque psoriasis above 18 years old, and matched with age and sex of 40 healthy individuals (control group), dermatologic examination was done by using the Psoriasis Area and Severity Index (PASI) score. Entire cases underwent laboratory tests for their serum concentration of OPN and IL-17. Results: The mean OPN level was significantly higher in the psoriasis group (21.5±11.7) compared to the control group. The mean IL17 level was significantly increased in the control group (82.6±47.7) compared to the psoriasis group (52.5±54.2). There was a positive significant correlation between IL-17 and PV severity. In discriminating between psoriasis cases and the control group, the AUC for OPN was 0.767, for IL17 it was 0.720, and for the combination of OPN and IL17 it was 0.821. The cut-off value for OPN was greater than 13.3, while for IL17 it was less than 60.9. Conclusion: the results suggested that OPN and IL17 levels have reasonable discriminative ability in distinguishing psoriasis cases from the control group. Moreover, the combination of OPN and IL17 shows slightly improved performance compared to either parameter alone. | ||
| Keywords | ||
| Osteopontin; IL-17; Psoriasis; PASI | ||
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