Radioprotective agents against ionizing radiation induced cellular damage. (Review) | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Articles in Press, Accepted Manuscript, Available Online from 10 June 2025 | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/bfsa.2025.368167.2504 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Abd elmoneim A.H. Taha  1; Ramadan A. M. Hemeida2; Amira M Abo-youssef3; Waleed A.I. Khallaf4; Mohamed I.A. Hassan5; Omer A.M. Hammad6
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| 1Department of pharmacology and toxicology | ||||
| 2Department of pharmacology, Faculty of pharmacy, Deraya University | ||||
| 3Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt | ||||
| 4Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt | ||||
| 5Department of pharmacology and toxicology,Faculty of pharmacy,Al Azhar university,Assiut | ||||
| 6Radiation Therapy and Nuclear Medicine Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Abstract Radioprotective compounds are vital for protecting biological systems exposed to radiation, whether from natural sources or radiation leaks. Additionally, these molecules safeguard the normal cells from irradiation damage in cancer patients undergoing radiation therapy. A great number of agents have been documented to demonstrate prospective therapeutic value. It is of the utmost importance to thoroughly investigate radioprotectors and the mechanisms by which they work, considering the potential therapeutic applications of these substances. This review explains the extensive scientific and pharmacological account of radioprotectors from natural source such as Glutathione, Vitamin E (αTocopherol), Vitamin C (Ascorbic acid), Curcumin, and alpha lipoic acid or synthetic sources such as amifostine, omeprazole, cimetidine.The development of radioprotective medicines that show therapeutic promise is a pursuit that researchers are constantly working toward. This review article presents a fresh assessment of radioprotectors' impact on several cellular signaling pathways. It lays the framework for the scientific community to develop revolutionary compounds that have increased therapeutic efficacy. This article provides an analysis of various radioprotective medications, with a particular focus on strategies for developing revolutionary radioprotective agents in the field of pharmaceutical research. In addition, the tactics that will be utilized to create radioprotectors in the future are discussed. | ||||
| Keywords | ||||
| -Keywords: Cellular damage; Ionizing radiation; Molecular mechanism; Radioprotective agents | ||||
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