Exploring the interplay between Celiac disease and gut microbiota: Mechanisms and implications | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 10 June 2025 | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/mid.2025.386844.2819 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Zahra’a Abdul AL-Aziz Yousif   1; Zainab Jumaah Fadhil2; Farah A. AL-waeely3
| ||||
| 1Ph.D. Medical Microbiology, Ibn Sina University of Medical and Pharmaceutical sciences, Baghdad, Iraq. | ||||
| 2Ph.D. Medical Microbiology, Department of Microbiology , College of medicine, Al-Iraqia University, Baghdad , Iraq. | ||||
| 3Ph.D. Medical Microbiology, Department of Medical Microbiology, medicine collage, Karbala University, Karbala, Iraq | ||||
| Abstract | ||||
| Background: For genetically sensitive people dietary gluten intake causes a persistent immune-mediated enteropathy known as celiac disease (CD). Emerging research suggests that the gut microbiota is critical to the development and progression of CD. It occurs in genetically predisposed children and adults who develop an immune response to gluten. Research indicates that these genetic factors significantly influence gut microbiota composition, with HLA-DQ2 carriers exhibiting distinct microbial profiles compared to non-carriers. For instance, infants with the HLA-DQ2 genotype showed higher levels of Firmicutes and Proteobacteria, and lower levels of Bifidobacterium, suggesting a microbiota composition that may increase CD risk. This review summarizes current studies on the bidirectional link between CD and gut microbiota, examining molecular pathways and clinical consequences. We look at dysbiotic patterns in CD microbiomes, the effect of gluten-free diets on microbial composition, and how specific bacterial taxa affect gluten processing, intestinal permeability, and immunological response. Understanding these complicated relationships provides important insights for generating novel diagnostic biomarkers and treatment approaches that go beyond gluten exclusion. | ||||
| Keywords | ||||
| Autoimmune disease; HLA-DQ2; HLA-DQ8; Microbiota; CD | ||||
|
Statistics Article View: 82 |
||||
