Synthesis and Antimicrobial Activity of Novel 2,6-diundecylidenecyclohexan-1-one Derivatives | ||||
Egyptian Journal of Chemistry | ||||
Articles in Press, Accepted Manuscript, Available Online from 11 June 2025 | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2025.373402.11566 | ||||
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Authors | ||||
Mahmoud Nabil Mahmoud Yousif ![]() ![]() ![]() | ||||
1Department of Photochemistry, National Research Centre, Cairo, Egypt | ||||
2Pesticide Chemistry Department, National Research Centre, Egypt | ||||
3Photochemistry Department, National Research Centre, Egypt | ||||
4Faculty of science, Al-Azhar University | ||||
5Natural and Microbial chemistry Department, National Research Center, Egypt | ||||
Abstract | ||||
Twelve newly prepared compounds starting from cycloheanone are done. Cyclohexanone reacts with undecanal to afford 2,6-diundecylidenecyclohexan-1-one 1. 2,6-Diundecylidenecyclohexan-1-one 1 reacts with urea, and thiourea to afford quinazoline derivatives 2a,b. Cyclohexanone derivative 1 reacts with guanidine, and aminoguanidine to form quinazoline derivatives 3a,b. Compound 1 reacts with semicarbazide, and thiosemicarbazide to give indazole derivatives 4a,b. Also, cyclohexanone derivative 1 reacts with carbon disulfide to afford benzo[b]thiophene derivative 5. Cyclohexanone derivative 1 reacts with hydrazine hydrate, and hydroxylamine to form indazole derivatives 6a,b. Quinazoline derivative 3b reacts with p-chlorobenzaldehyde to afford octahydroquinazoline derivative 7. Also, quinazoline derivative 3b reacts with ribose, and glucose to afford sugar derivatives 8a,b. Antimicrobial screening of new prepared compounds was done against G+ve bacteria, G-ve bacteria, and two fungi. Several compounds show promising antimicrobial activity as compared with reference drug used. | ||||
Keywords | ||||
Diundecylidenecyclohexan-1-one derivatives; quinazoline derivatives; indazole derivatives; benzo[b]oxazole derivatives; benzo[b]thiophene; antimicrobial activity | ||||
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