Synthesis and Antimicrobial Activity of Novel 2,6-diundecylidenecyclohexan-1-one Derivatives | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 13, December 2025, Pages 903-909 PDF (178.53 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2025.373402.11566 | ||
| Authors | ||
| Mahmoud Nabil Mahmoud Yousif* 1; Ahmed ElRashedy2; Mohamed El-Shehry3; Ahmed Saber4 | ||
| 1Department of Photochemistry, National Research Centre, Cairo, Egypt | ||
| 2Natural and Microbial chemistry Department, National Research Center, Egypt | ||
| 3Pesticide Chemistry Department, National Research Centre, Egypt | ||
| 4Faculty of science, Al-Azhar University | ||
| Abstract | ||
| Twelve newly prepared compounds starting from cycloheanone are done. Cyclohexanone reacts with undecanal to afford 2,6-diundecylidenecyclohexan-1-one 1. 2,6-Diundecylidenecyclohexan-1-one 1 reacts with urea, and thiourea to afford quinazoline derivatives 2a,b. Cyclohexanone derivative 1 reacts with guanidine, and aminoguanidine to form quinazoline derivatives 3a,b. Compound 1 reacts with semicarbazide, and thiosemicarbazide to give indazole derivatives 4a,b. Also, cyclohexanone derivative 1 reacts with carbon disulfide to afford benzo[b]thiophene derivative 5. Cyclohexanone derivative 1 reacts with hydrazine hydrate, and hydroxylamine to form indazole derivatives 6a,b. Quinazoline derivative 3b reacts with p-chlorobenzaldehyde to afford octahydroquinazoline derivative 7. Also, quinazoline derivative 3b reacts with ribose, and glucose to afford sugar derivatives 8a,b. Antimicrobial screening of new prepared compounds was done against G+ve bacteria, G-ve bacteria, and two fungi. Several compounds show promising antimicrobial activity as compared with reference drug used. | ||
| Keywords | ||
| Diundecylidenecyclohexan-1-one derivatives; quinazoline derivatives; indazole derivatives; benzo[b]oxazole derivatives; benzo[b]thiophene; antimicrobial activity | ||
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