Enhanced Anticancer Potential of Selenium-Incorporated Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Cytotoxic Evaluation. | ||
| Mansoura Journal of Chemistry | ||
| Volume 68, Issue 3, September 2025, Pages 11-16 PDF (929.07 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/mjcc.2025.388090.1012 | ||
| Authors | ||
| Badihan khaled Elmorsy* 1; Omali Elkhawaga2; Emad Tolba3; Zakaria El-Khayat4 | ||
| 1Biochemistry Department, Faculty of Science, Mansoura University, Egypt. | ||
| 2Chemistry | ||
| 3Polymers and Pigments Department National Research center | ||
| 4Medical Biochemistry Department, National Research Center | ||
| Abstract | ||
| The field of inorganic nanoparticle (NP) synthesis has indeed expanded significantly, driven by the demand for multifunctional biomaterials that address key challenges in biomedical applications. In this research, selenium-incorporated hydroxyapatite nanoparticles were produced by in situ chemical reaction, and their nanoparticles' biological activity was examined against two distinct cell lines: the human hepatocellular carcinoma cell line (HepG2) and the human breast cancer cell (MCF7). Additionally, x-ray diffraction (XRD) and transition electron microscopy (TEM) analyses of the obtained calcium phosphate-based nanoparticles revealed the formation of needle-like nanoparticles with an average particle size of less than 100 nm and a high aspect ratio of up to 9 for the Se2-HA sample, depending on the selenium concentration.Interestingly, the in vitro cell viability studies indicate that Se-HANPs had lower half-maximal inhibitory concentration (IC50) values than pure HA, which suggests that they are more cytotoxic to cancer cells and could be used as anticancer therapy. | ||
| Keywords | ||
| selenium-calcium phosphate nanoparticles; hydroxyapatite; anticancer therapy; biomaterials; cell culture | ||
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