The effect of various solvent on the total phenol content, the total flavonoid content, the antioxidant activity of Erica arborea extracts from Algeria and investigation of their Antibacterial activity against multi drug‐resistant uropathogenic bacte | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Articles in Press, Accepted Manuscript, Available Online from 14 June 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2025.368366.2474 | ||||
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| Authors | ||||
Saida Hanoun   1; Kelthoum Ahmed-Gaid 2; Houssem Chenna3; Mouna BOUFAFA4; Khaoula AROUA5; Hanane Mellal6
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| 1Department of Molecular and Cellular Biology, Faculty of Natural and life Sciences, University of Abbes Laghrour, 40004, Khenchela, Algeria Applied Molecular and Cellular Biology, Faculty of Natural and life Sciences, University of | ||||
| 2Department of Biological and Agricultural Sciences, Institute of Sciences and Technology, AbdelHafid Boussouf University Center, 43000, Mila, Algeria | ||||
| 3Pharmaceutical Sciences Research Center (CRSP), Constantine, 25000, Algeria. | ||||
| 4Laboratory of Eco-biology for Marine Environment and Coastlines Department of Biochemistry University of Badji Mokhtar, Annaba, Algeria | ||||
| 5Department of Agronomy, Faculty of Natural and Life Sciences, Abbes Laghrour University 40004, Khenchela, Algeria | ||||
| 6Department of Molecular and Cellular Biology, Faculty of Natural and life Sciences, University of Abbes Laghrour, 40004, Khenchela, Algeria. | ||||
| Abstract | ||||
| Erica arborea is a shrub that is known in Algeria as Khelenj and is recommended in Algerian folk medicine for treating and preventing primarily acute or chronic urinary infections. This work aimed to investigate the antibacterial activity of methanol, ethanol and acetone extracts of Erica arborea against multidrug‐resistant uropathogenic bacteria and to determine their potential antioxidant activity. The antibacterial activity of the plant extracts was determined by disc diffusion against Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 700603 and five multi drug‐resistant uropathogenic clinical strains: Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter spp., Escherichia coli 1, Escherichia coli 36 and Escherichia coli 37. The antioxidant activity was evaluated using the DPPH radical scavenging assay. The results of the antibacterial activity demonstrated that the ethanol extract had moderate antibacterial activity against Pseudomonas aeruginosa ATCC 27853 and strong activity against Klebsiella pneumoniae ATCC 700603. The methanol extract showed antibacterial activity against Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 700603, Escherichia coli ATCC 25922 and the clinical isolates of K. pneumonia, P. aeruginosa and E. coli 1. However, acetone extract was the most effective and showed antibacterial activity against all tested strains at the concentration of 200mg/ml. For the antioxidant activity, the obtained values corresponding to 55, 49±0, 56, 55, 66±0, 29 and 55, 78±0, 07 (mg TEs/g extract) for methanol, acetone, and ethanol extracts, respectively. These findings suggest the promising therapeutic of these plant extracts and provide pharmacological evidence in ethno-medicine for the management of diseases caused by uropathogenic microorganisms. | ||||
| Keywords | ||||
| Erica arborea; antioxidant activity; antibacterial activity; multidrug‐resistant uropathogenic bacteria | ||||
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