Gold Nanoparticles in Drug Delivery Systems for Cancer Treatment: A Review
Ramadan, A., Abdullah, H., Nabet, R., Shehata, R., Gohar, M., Elmorsy, A., Elteray, N., Elseddiq, H., shreeda, D., Abd Almotaleb, E., Mohammed, E., Aldesouky, A., El Adlany, D., Ahmed, S., Maarouf, S., Galal, F., kiwan, M., Mohamed, M., Mohamed, N., Sabry, M., Abdelrazik, H., Abd Elhamid, A., Hassanen, A., Fathi, A., Sorour, K., Kamal, I. (2025). Gold Nanoparticles in Drug Delivery Systems for Cancer Treatment: A Review. EKB Journal Management System, 7(1), 35-48. doi: 10.21608/odr.2025.380813.1053
Abd El hakim Ramadan; Hend Diaa Abdullah; Refaa Yousry Nabet; Rana Ahmed Shehata; Mohamed Hasssanen Gohar; Alaa Hamdy Elmorsy; Norhan Ali Elteray; Hossam Mohamed Elseddiq; Dalia Adel shreeda; Eslam Ahmed Abd Almotaleb; Esraa Helmy Mohammed; Alaa Gehad Aldesouky; Dina Emad El Adlany; Sameh Ashraf Ahmed; Shahd Mohamed Maarouf; Fatma Nour Galal; Manar Elsayed kiwan; Manar Mohamed Mohamed; Nada Ashraf Mohamed; Mohammed Sobhy Sabry; Hend Abdelsabour Abdelrazik; Alaa Salama Abd Elhamid; Abdelrahman Mohammed Ahmed Hassanen; AbdelRhman Ebrahim Fathi; Karim Ahmed Sorour; Islam Kamal. "Gold Nanoparticles in Drug Delivery Systems for Cancer Treatment: A Review". EKB Journal Management System, 7, 1, 2025, 35-48. doi: 10.21608/odr.2025.380813.1053
Ramadan, A., Abdullah, H., Nabet, R., Shehata, R., Gohar, M., Elmorsy, A., Elteray, N., Elseddiq, H., shreeda, D., Abd Almotaleb, E., Mohammed, E., Aldesouky, A., El Adlany, D., Ahmed, S., Maarouf, S., Galal, F., kiwan, M., Mohamed, M., Mohamed, N., Sabry, M., Abdelrazik, H., Abd Elhamid, A., Hassanen, A., Fathi, A., Sorour, K., Kamal, I. (2025). 'Gold Nanoparticles in Drug Delivery Systems for Cancer Treatment: A Review', EKB Journal Management System, 7(1), pp. 35-48. doi: 10.21608/odr.2025.380813.1053
Ramadan, A., Abdullah, H., Nabet, R., Shehata, R., Gohar, M., Elmorsy, A., Elteray, N., Elseddiq, H., shreeda, D., Abd Almotaleb, E., Mohammed, E., Aldesouky, A., El Adlany, D., Ahmed, S., Maarouf, S., Galal, F., kiwan, M., Mohamed, M., Mohamed, N., Sabry, M., Abdelrazik, H., Abd Elhamid, A., Hassanen, A., Fathi, A., Sorour, K., Kamal, I. Gold Nanoparticles in Drug Delivery Systems for Cancer Treatment: A Review. EKB Journal Management System, 2025; 7(1): 35-48. doi: 10.21608/odr.2025.380813.1053

Gold Nanoparticles in Drug Delivery Systems for Cancer Treatment: A Review

Octahedron Drug Research
Volume 7, Issue 1, June 2025, Page 35-48  XML PDF (760.5 K)
Document Type: Review Articles
DOI: 10.21608/odr.2025.380813.1053
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Authors
Abd El hakim Ramadan; Hend Diaa Abdullah email orcid ; Refaa Yousry Nabet; Rana Ahmed Shehata; Mohamed Hasssanen Gohar; Alaa Hamdy Elmorsy; Norhan Ali Elteray; Hossam Mohamed Elseddiq; Dalia Adel shreeda; Eslam Ahmed Abd Almotaleb; Esraa Helmy Mohammed; Alaa Gehad Aldesouky; Dina Emad El Adlany; Sameh Ashraf Ahmed; Shahd Mohamed Maarouf; Fatma Nour Galal; Manar Elsayed kiwan; Manar Mohamed Mohamed; Nada Ashraf Mohamed; Mohammed Sobhy Sabry; Hend Abdelsabour Abdelrazik; Alaa Salama Abd Elhamid; Abdelrahman Mohammed Ahmed Hassanen; AbdelRhman Ebrahim Fathi; Karim Ahmed Sorour; Islam Kamal
23 December street
Abstract
Gold nanoparticles (AuNPs) have emerged as a promising nano-carrier in cancer therapy due to their unique physicochemical properties, including high stability, biocompatibility, and surface tunability. This review explores synthesis and functionalization of AuNPs. In addition, the roles of AuNPs in drug delivery systems, highlighting their advantages over conventional cancer treatments, such as improved targeting, enhanced drug bioavailability, and reduced systemic toxicity, are deliberated. Moreover, the mechanisms of AuNP-based drug delivery include passive targeting via the enhanced permeability and retention (EPR) effect and active targeting using functionalized ligands are illustrated. Additionally, stimuli-responsive drug release strategies, including pH, temperature, and light-triggered mechanisms, are discussed. This review underscores the transformative potential of AuNPs in the treatment of different cancer types while emphasizing the need for further research to optimize their clinical applicability. Furthermore, their toxicity, biocompatibility, and safe dosage limits are highlighted. Finally, clinical trials and regulatory considerations of FDA and EMA are mentioned.
Keywords
Gold nanoparticles; Drug delivery; Targeted therapy; Controlled release; Cancer treatment
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