Chinese cinnamon essential oil as a potential dental additive: Antimicrobial efficacy and biocompatibility assessment | ||||
Scientific Journal for Damietta Faculty of Science | ||||
Volume 15, Issue 2, August 2025, Page 12-23 PDF (941.72 K) | ||||
Document Type: Original articles | ||||
DOI: 10.21608/sjdfs.2025.374410.1225 | ||||
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Authors | ||||
Rana El Sadda1; Rahma A.M. Abobakr2; Reham M. Abdallah3; ElHossein A. Moawed4; Mohamed M. El-Zahed ![]() ![]() | ||||
1Chemistry department , faculty of science, Damietta university | ||||
21Damietta University, Faculty of Science, Chemistry Department, New Damietta, Egypt. 2 Bani Waleed University, Faculty of Medical Technology, Department of Dental Technology, Bani Waleed, Libya. | ||||
31Mansoura University, Faculty of Dentistry, Department of Dental Biomaterials, Mansoura, Egypt. 2Horus University, Faculty of Dentistry, Department of Dental Biomaterials, New Damietta, Egypt. | ||||
4Chemistry Department, Faculty of Science, Damietta University, Egypt | ||||
5Department of Botany and Microbiology, Faculty of Science, Damietta University, New Damietta, Egypt. | ||||
Abstract | ||||
The objective of this study was to assess the antimicrobial potential and biosafe dose of Chinese cassia essential oil (CCEO) to be biocompatible for dental applications. CCEO extract was obtained by soaking Chinese cassia sticks in 3 solvents: petroleum ether, chloroform, and methyl alcohol. FTIR and GC-MS spectrometry investigations were used to study the chemical composition of CCEO extract. FTIR showed the presence of O-H functional group that is related to phenols and alcohols, C-H stretching for alkane, C =O bond for aldehyde of saturated fatty acids, C=C bond for alkenes, C-OH bending vibration of alcohols, and C-O-C for aromatic acid esters. The GC-MS results indicated the presence of 36 diverse compounds. Amongst these, E-cinnamaldehyde (38.08%), (7.99%) of carbohydrates (D-Talofuranose, D-Talopyranose, D-Mannopyranose and D- Glucopyranose), p-Coumaric alcohol (7.44%), Cinnamyl alcohol (6.15%) and Cinnamic acid (6.11%) were the most plentiful compounds. The antimicrobial action of the CCEO was tested against Candida albicans, methicillin-resistant S. aureus (MRSA), and Enterobacter aerogenes which displayed memorable antimicrobial activity against all tested microorganisms. CCEO revealed minimum inhibition concentration values of 15 µl/ml, 5 µl/ml, and 25 µl/ml against C. albicans, MRSA, and E. aerogenes, respectively. In addition, the biocompatibility of CCEO was evaluated on the oral cells. Biosafe dose analysis highlighted the necessity of carefully evaluating oil biocompatibility for dental applications, as excessive concentrations may compromise cell membrane integrity, induce oxidative stress, and trigger inflammatory responses. CCEO displayed to be a highly promising supplementary additive to improving antimicrobial and biosafe properties. | ||||
Keywords | ||||
Chinese cassia; antimicrobial; biocompatibility; dental; inflammatory | ||||
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