Some immunological studies in cohort of systemic lupus erythematosus patients
Kamal El-Din, A., Abd El-hakeem, M., ismail, F., Mousa, N., Mohamed, A. (2025). Some immunological studies in cohort of systemic lupus erythematosus patients. EKB Journal Management System, (), -. doi: 10.21608/mjmr.2025.392264.1977
Amel Mahmoud Kamal El-Din; Mohammed Abd El-razek Abd El-hakeem; faten ismail; Norhan Mohamed Mousa; Ayat Moustafa Mohamed. "Some immunological studies in cohort of systemic lupus erythematosus patients". EKB Journal Management System, , , 2025, -. doi: 10.21608/mjmr.2025.392264.1977
Kamal El-Din, A., Abd El-hakeem, M., ismail, F., Mousa, N., Mohamed, A. (2025). 'Some immunological studies in cohort of systemic lupus erythematosus patients', EKB Journal Management System, (), pp. -. doi: 10.21608/mjmr.2025.392264.1977
Kamal El-Din, A., Abd El-hakeem, M., ismail, F., Mousa, N., Mohamed, A. Some immunological studies in cohort of systemic lupus erythematosus patients. EKB Journal Management System, 2025; (): -. doi: 10.21608/mjmr.2025.392264.1977

Some immunological studies in cohort of systemic lupus erythematosus patients

Minia Journal of Medical Research
Articles in Press, Accepted Manuscript, Available Online from 15 June 2025  XML
Document Type: Original Article
DOI: 10.21608/mjmr.2025.392264.1977
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Authors
Amel Mahmoud Kamal El-Din1; Mohammed Abd El-razek Abd El-hakeem2; faten ismail3; Norhan Mohamed Mousa email 4; Ayat Moustafa Mohamed5
1clinical pathology faculty of medicine Minia university El minia Egypt
2clinical pathology, Faculty of Medicine, Minia University
3rheumatology department minia university
4Department of Clinical Pathology, Faculty of Medicine, Minia University, Minia, Egypt.
5Department of Clinical Pathology, faculty of medicine, Minia University, Minia, Egypt
Abstract
Background and aim of the study: Systemic lupus erythematosus (SLE) is an autoimmune disease affecting all body organs. Beside genetic, hormonal and environmental variables, unbalance between pro-inflammatory and anti-inflammatory cytokines leads to alteration of the immune system and promote tissue damage. Antinuclear antibody (ANA) and anti–double-stranded DNA (Anti-dsDNA) both play central role in both diagnosis and monitoring of SLE. This study aimed to evaluate role of ANA and Anti ds-DNA and their correlation with other laboratory markers.

Methodology: The study included ninety subjects: 40 healthy individuals as control group and 50 SLE patients. SLE patients were diagnosed according to The European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) 2019 criteria for SLE. ANA and Anti ds-DNA level were assessed by EIA method.

Results: There was statistically significant increase in group I regarding ANA, Anti ds-DNA, ESR, CRP , blood culture, blood urea , A/C ratio and neutrophilic count compared to group II, ANA showed statistically significant positive correlation with CRP ,urea, creatinine, while Anti-ds DNA showed statistically significant negative correlation with neutrophilic and monocytic count.

Conclusion: This study demonstrated increased level of ANA and Anti ds-DNA in SLE patients than controls which play a significant role in early diagnosis and monitoring of SLE patients.
Keywords
SLE; ANA; Anti ds-DNA
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