The Significance of Immunohistochemical Expression of Sphingosine Kinase-1 and Galectin-3 in Differentiation Between Follicular Adenoma, Non-invasive Follicular Tumor with Papillary Nuclear Features and Follicular Variant Papillary Thyroid Carcinoma | ||||
| SECI Oncology Journal | ||||
| Volume 13, Issue 2, April 2025, Page 172-178 PDF (724.02 K) | ||||
| DOI: 10.21608/secioj.2025.433332 | ||||
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| Abstract | ||||
| Background and Study Aims: This study aims to evaluate the frequency of sphingosine kinase-1 (SPHK-1) and galectin 3 (Gal-3) immunohistochemical (IHC) expression in noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), follicular adenoma (FA), and follicular variant of papillary thyroid carcinoma (FVPTC), as well as the relationship between SPHK-1 and Gal 3 IHC expression in these thyroid lesions. Patients and Methods: 56 individuals underwent IHC analysis to evaluate the expression of the SPHK-1 and Gal-3 proteins. Results: The findings showed a significant correlation between FVPTC and elevated expression of SPHK-1 and Gal-3 (p < 0.001 for both markers). Gal-3 expression did not vary statistically significantly between FA and NIFTP patients (p = 0.271). The difference in the expression of SPHK-1 in FA and NIFTP patients was statistically significant (p < 0.001). Conclusions: Our results showed that both SPHK-1 and Gal-3 expression have diagnostic value for FVPTC. As an innovative strategy, only SPHK-1 could be used as a diagnostic factor for NIFTP. | ||||
| Keywords | ||||
| Sphingosine kinase 1; Galectin-3; Immunohistochemistry (IHC); Follicular adenoma (FA); Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); Follicular variant of papillary thyroid carcinoma (FVPTC); Thyroid neoplasms; Thyroid tumor biomarkers | ||||
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