Antibacterial effect of selected plant extracts against clinical isolates of Staphylococcus aureus | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 16 June 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2025.388633.2832 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ashwak jasim kzar   1; Mhamed M. Sehree* 2
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| 1Department of Medical Laboratory Technology, College of Health and Medical Techniques Middle Technical University, Iraq | ||||
| 2College of Nursing , University of Telafer, Iraq | ||||
| Abstract | ||||
| Background: Staphylococcus aureus is a commom caus of nosocomial infection. The major problem in the didtribution of theses bacteria is ability to resistance to antibiotics. The the study aimed to effect of plant extracts effect of various plant extracts (garlic, curcumin, and Syzygium aromaticum ) on inhibitin the (25) growth of Staphylococcus aureus was studied by assessing their impact on the bacteria's susceptibility to antibiotics. The determine the inhibitory activity of plant extracts against this bacterium with the aim of exploring their potential as alternative treatments for bacterial infections. The study included assessing the susceptibility of S. aureus isolates to a variety of antibiotics, as well as examining their resistance to aqueous and ethanolic plant, with the plant extract showing the highest inhibitory activity against the bacteria being identified. Methods: Pathogenic Staphylococcus aureus isolates were subjected to antibiotic susceptibility testing using six therapeutic agents: clindamycin (CD), doxycycline (DO), levofloxacin (LEV), cephalexin (CN), ofloxacin (OFX), and praxinamycin (PR). All isolates demonstrated significant susceptibility to clindamycin and doxycycline. Furthermore, the resistance of these strains to two different plant extracts was evaluated by nutrient agar diffusion technique. The extracts used included aqueous (Aq) and ethanolic (E) extracts derived from garlic, curcumin, and Syzygium aromaticum. Results: The study results showed that all ethanolic extracts of Syzygium aromaticum were most effective in inhibiting the growth of Staphylococcus aureus, with larger growth inhibition zones than the other extracts. This suggests that the plant contains active compounds better soluble in ethanol and contribute to its antibacterial activity. Furthermore, among the three aqueous extracts of garlic, curcumin, and Syzygium aromaticum, the curcumin extract was most effective, showing the most significant inhibitory effect on S. aureus growth compared to the other aqueous extracts, reflecting the potential presence of water-soluble active compounds that contribute to bacterial inhibition. Conclusion: This study highlights the effective role of the three studied plant extracts in exhibiting unique and specific antibacterial activity against Staphylococcus aureus. These results enhance the possibility of exploiting these plants as promising natural sources for developing alternative and effective treatments to combat bacterial infections, especially in light of the increasing challenges related to antibiotic resistance. They also open new research avenues to deepen scientific understanding of the biological mechanisms of plant extracts and their use in the design of anti-infective drugs with high efficacy and improved safety. | ||||
| Keywords | ||||
| Antibacterials; Bacterial disease; Staphylococcus aureus; plant extracts | ||||
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