Biochemical Activity of Chalcone Derivatives as Target-Oriented Anti-cancer Agents | ||||
| Advances in Environmental and Life Sciences | ||||
| Articles in Press, Accepted Manuscript, Available Online from 17 June 2025 | ||||
| Document Type: Reviews Articles. | ||||
| DOI: 10.21608/aels.2025.387647.1078 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sara F Goda  ; Mohamed S. Nafie; Elsayed H. Eltamany
| ||||
| Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt | ||||
| Abstract | ||||
| Cancer remains a major health burden globally, characterized by uncontrolled cell growth, resistance to therapy, and adverse side effects from current treatments such as chemotherapy. Chalcones, naturally derived phytochemicals, present a promising avenue for anticancer therapy due to their affordability, availability, and low toxicity. This study evaluates the anticancer efficacy of novel polymethylated chalcone derivatives synthesized via reactions involving 2,3,5,6-tetramethylbenzaldehyde and acetophenone. The chalcones were tested against human cancer cell lines and in vivo models, comparing their effects to the standard chemotherapy drug 5-fluorouracil (5-FU). The synthesized compounds demonstrated significant antiproliferative activity, induced apoptosis, and caused G2/M cell cycle arrest. In vivo studies showed reduced tumor size, improved survival rates, and minimal adverse effects on liver and kidney functions compared to 5-FU. These findings underscore the potential of polymethylated chalcone derivatives as targeted anticancer agents, paving the way for further studies and potential clinical applications. s . s. s. s. | ||||
| Keywords | ||||
| Cancer; Biochemical Activity; Chalcone; polymethylated chalcone derivatives | ||||
|
Statistics Article View: 58 |
||||
