CANDIDA ALBICANS COLONIZATION ON DENTURE BASE MATERIAL FABRICATED BY DIFFERENT METHODS (IN-VITRO STUDY)

Hegab, Ahmed Hesham; Shehat, Michael; Kamal, Sara; Ezzelarab, Salah; Segaan, Lucette

doi:10.21608/adjalexu.2025.360111.1594

	CANDIDA ALBICANS COLONIZATION ON DENTURE BASE MATERIAL FABRICATED BY DIFFERENT METHODS (IN-VITRO STUDY)
Alexandria Dental Journal
Articles in Press, Corrected Proof, Available Online from 18 June 2025 PDF (543.87 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2025.360111.1594
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Authors
Ahmed Hesham Hegab ¹; Michael Shehat ²; Sara Kamal¹; Salah Ezzelarab¹; Lucette Segaan³
¹Department of Prosthodontics, Faculty of Dentistry, Alexandria University, Egypt
²Champolion st., Azarita
³Professor, Department of Prosthodontics, Faculty of dentistry, Alexandria university, Alexandria, Egypt.
Abstract
Introduction: The increased incidence of oral Candidiasis infections has been accompanied by the rise of the immunosuppressed population. Dentures provide an environment that encourages the attachment and proliferation of potentially harmful organisms. The roughness and wettability of denture base resin surfaces are significant factors in facilitating C. albicans adherence. Objectives: Compare the effect of different denture fabrication methods on C. albicans adherence and proliferation. Materials and methods: 40 specimens were prepared for this study, divided into four groups of different denture base resins which were fabricated using different techniques. Group I was fabricated using heat-cure polymethyl methacrylate (PMMA). Group II was fabricated by the CAD-CAM milling method, while Group III was fabricated using the 3D-printing method and Group IV was fabricated using the thermoplastic injecting molding resin. C. albicans adherence was measured using two methods: Scanning electron microscope and Direct culture method. Results: There was a statistically significant difference in adherence among the studied groups. While there was a statistically significant difference in Surface Roughness & Contact Angle among the studied groups. Conclusion: Denture bases fabricated with the CAD/CAM milling method are superior to other fabricated methods revealing a higher contact angle and a lower surface roughness leading to a decreased adherence of C. albicans.
Keywords
C. albicans; Colonization; Denture Base; CAD/CAM milling; 3D printing


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