Revealing the unknown about titanium dioxide nanoparticles: Introduction to titanium dioxide: synthesis and uses in nanomedicine and pharmaceuticals
Abdullah, H., Ramadan, A., El Zmety, M., Salem, M., Abbas, M., Mostafa, M., Abdel Hakim, O., Mahmoud, A., El Gazar, A., El Amir, H., Mostafa, M., El Boghdady, M., Awadein, O., El Sayed, O., El Hattab, O., Saleh, M., Mohamed, N., Metwally, Z., Wahib, S., Saeed, A., Ahmed, M., Mahmoud, M., Abo El Fetouh, H., Badr El Din, K., Kamal, I. (2025). Revealing the unknown about titanium dioxide nanoparticles: Introduction to titanium dioxide: synthesis and uses in nanomedicine and pharmaceuticals. EKB Journal Management System, (), -. doi: 10.21608/odr.2025.378894.1048
Hend Diaa Abdullah; Abd El hakim Ramadan; Moataz Ibrahim El Zmety; Mohamed Saeed Salem; Mohamed Abd El Aziz Abbas; Mohamed Magid Mostafa; Osama Arafat Abdel Hakim; Amr Samy Mahmoud; Ahmed Yassin El Gazar; Helmy Ali El Amir; Mazen Hisham Mostafa; Momen Yasser El Boghdady; Omar Khaled Awadein; Omar Osama El Sayed; Omar Mohamed El Hattab; Mohamed Nader Saleh; Nour El Din Ibrahim Mohamed; Zyad Mohamed Metwally; Sourial Samy Wahib; Ahmed Tarek Saeed; Mahmoud Hamed Ahmed; Mohamed Hosny Mahmoud; Hesham Hazem Abo El Fetouh; Khaled Ahmed Badr El Din; Islam Kamal. "Revealing the unknown about titanium dioxide nanoparticles: Introduction to titanium dioxide: synthesis and uses in nanomedicine and pharmaceuticals". EKB Journal Management System, , , 2025, -. doi: 10.21608/odr.2025.378894.1048
Abdullah, H., Ramadan, A., El Zmety, M., Salem, M., Abbas, M., Mostafa, M., Abdel Hakim, O., Mahmoud, A., El Gazar, A., El Amir, H., Mostafa, M., El Boghdady, M., Awadein, O., El Sayed, O., El Hattab, O., Saleh, M., Mohamed, N., Metwally, Z., Wahib, S., Saeed, A., Ahmed, M., Mahmoud, M., Abo El Fetouh, H., Badr El Din, K., Kamal, I. (2025). 'Revealing the unknown about titanium dioxide nanoparticles: Introduction to titanium dioxide: synthesis and uses in nanomedicine and pharmaceuticals', EKB Journal Management System, (), pp. -. doi: 10.21608/odr.2025.378894.1048
Abdullah, H., Ramadan, A., El Zmety, M., Salem, M., Abbas, M., Mostafa, M., Abdel Hakim, O., Mahmoud, A., El Gazar, A., El Amir, H., Mostafa, M., El Boghdady, M., Awadein, O., El Sayed, O., El Hattab, O., Saleh, M., Mohamed, N., Metwally, Z., Wahib, S., Saeed, A., Ahmed, M., Mahmoud, M., Abo El Fetouh, H., Badr El Din, K., Kamal, I. Revealing the unknown about titanium dioxide nanoparticles: Introduction to titanium dioxide: synthesis and uses in nanomedicine and pharmaceuticals. EKB Journal Management System, 2025; (): -. doi: 10.21608/odr.2025.378894.1048

Revealing the unknown about titanium dioxide nanoparticles: Introduction to titanium dioxide: synthesis and uses in nanomedicine and pharmaceuticals

Octahedron Drug Research
Articles in Press, Accepted Manuscript, Available Online from 18 June 2025  XML
Document Type: Review Articles
DOI: 10.21608/odr.2025.378894.1048
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Authors
Hend Diaa Abdullah email orcid ; Abd El hakim Ramadan; Moataz Ibrahim El Zmety; Mohamed Saeed Salem; Mohamed Abd El Aziz Abbas; Mohamed Magid Mostafa; Osama Arafat Abdel Hakim; Amr Samy Mahmoud; Ahmed Yassin El Gazar; Helmy Ali El Amir; Mazen Hisham Mostafa; Momen Yasser El Boghdady; Omar Khaled Awadein; Omar Osama El Sayed; Omar Mohamed El Hattab; Mohamed Nader Saleh; Nour El Din Ibrahim Mohamed; Zyad Mohamed Metwally; Sourial Samy Wahib; Ahmed Tarek Saeed; Mahmoud Hamed Ahmed; Mohamed Hosny Mahmoud; Hesham Hazem Abo El Fetouh; Khaled Ahmed Badr El Din; Islam Kamal
23 December street
Abstract
Titanium dioxide (TiO₂) nanoparticles are among the most widely studied nanomaterials due to their unique physical and chemical properties, including high surface area, photocatalytic activity, and low toxicity. These characteristics make them especially valuable in medical and pharmaceutical applications. TiO₂ nanoparticles can be used in cancer therapy, drug delivery systems, antimicrobial coatings, and biosensors. Their ability to generate reactive oxygen species under UV light enables targeted therapeutic effects, particularly in cancer treatment. The method of synthesis significantly affects their size, shape, surface properties, and functionality. Common synthesis techniques include sol-gel, hydrothermal, and precipitation methods, while green synthesis using plant extracts has recently gained popularity for its eco-friendly nature. Each method offers specific advantages that influence the nanoparticles’ suitability for biomedical use. As TiO₂-based nanotechnology continues to evolve, understanding these synthesis methods is crucial for developing safe and effective medical applications. This paper provides an overview of the synthesis techniques and highlights the growing role of TiO₂ nanoparticles in modern medicine.
Keywords
Nanotechnology; Titanium dioxide nanoparticles (TiO NPs); Green synthesis; Reactive Oxygen Species (ROS); and Cancer treatment
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