Value of CD200 and CD47 expression in human acute myeloid leukemia cells | ||||
| Journal of Recent Advances in Medicine | ||||
| Articles in Press, Accepted Manuscript, Available Online from 18 June 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jram.2025.365897.1281 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Eman Emad Eldien Mostafa  1; Randa Amin Osman2; Samar Mohammed Abd Elhamid3; Mona Hilmy Alrayes4
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| 1Clinical pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo | ||||
| 2Clinical Pathology Department ,National Cancer Institute ,Cairo University | ||||
| 3Clinical Pathology Department, Faculty of Medicine for Girls - Al-Azhar University, Cairo. | ||||
| 4Clinical Pathology Department, Faculty of medicine for Girls, Al-Azhar university, Cairo | ||||
| Abstract | ||||
| Background: Acute myeloid leukemia (AML) is the commonest type of leukemia in adults. Increased potential for metastasis, aggressive tumor development, and decreased patient survival have all been linked to CD200 overexpression on tumor cells. CD47 on malignant cells has been shown to regulate acquisition of tumor-initiating ability, metastasis formation and inducing treatment resistance. Objective: to assess the significance of CD200 and CD47 expression on blasts in acute myeloid leukemia, also a comparison between AML with myeloid differentiation and AML with monocytic differentiation as regard the expression of these markers will be included. Patients and methods: Between January 2023 and January 2024; 51 adult patients with de novo AML were enrolled in this hospital based cross sectional study. They were selected from the Medical Oncology Department's outpatient clinic at the National Cancer Institute, Cairo University. Two categories of patients were established; AML with myeloid differentiation (M0/M1/M2) (n=24) and AML with monocytic differentiation (M4/M5) (n=27). The expression of CD200 and CD47 on blast cells by flow cytometer were measured. Results: The CD200% was higher in AML with myeloid differentiation compared to AML with monocytic differentiation (p=0.039). CD200 density was higher in M5 cases than in myeloid cases (p=0.029) and M4 cases (p=0.013). CD47 density was higher in M4 patients in comparison with myeloid patients (p=0.037). Conclusion: The % of myeloblasts expressing CD200 was significantly higher than the monoblasts expressing CD200, that could suggest a distinct role of CD200 in immune evasion mechanisms for myeloblasts. CD47 density was significantly higher in M4 group in comparison to AML with myeloid differentiation. CD200 density was significantly higher in M5 in comparison to both AML with myeloid differentiation and M4. Key words: Acute myeloid leukemia, Cluster of differentiation 200, Cluster of differentiation 47 | ||||
| Keywords | ||||
| Acute myeloid leukemia; Cluster of differentiation 200; Cluster of differentiation 47 | ||||
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