Sequence-based CLEC7A rs3901533 gene Polymorphisms Linked to Iraqi COVID-19 Patients | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Article 2, Volume 35, Issue 1, January 2026 | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
| DOI: 10.21608/ejmm.2025.389814.1676 | ||||
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| Authors | ||||
Ayad Abdelsalam  1; Marwa F. Alsaffar2; Zahraa H. Merza1; Zahraa A. Abdalameer3; Rzaq S. Kaurshead1
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| 1Radiology Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, 51001, Babylon, Iraq | ||||
| 2Medical Laboratory Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, Babylon, 51001, Iraq. | ||||
| 3Environmental Health Department, College of Environmental Sciences, AL-Qasim Green University, Babylon, 51013, Iraq | ||||
| Abstract | ||||
| Background: The genetic diversity of the hosts may have an impact on the clinical range of COVID-19 severity. Dectin-1, an integral component of the innate immune response to SARS-CoV-2, is encoded by the CLEC7A gene. Objectives: This study investigates the relationship between Iraqi patients' susceptibility to COVID-19 and CLEC7A rs3901533 (A/C) polymorphisms. Methodology: Twenty COVID-19 patients, twenty recovered people, and twenty healthy controls provided a total of sixty DNA samples. Using the sequencing method, the CLEC7A rs3901533 (A/C) polymorphisms were genotyped. Results: The frequencies of the A and C alleles were 45%, 52.5%, and 55%, respectively, in patients, recovered individuals, and controls, and 57.5%, 47.5%, and 45%, respectively. Among COVID-19 patients, the CC genotype was much more common (30%) than in controls (15%), indicating a strong correlation with higher susceptibility to the disease (P-value < 0.05). Conclusion: According to the results, the CC genotype of the CLEC7A rs3901533 polymorphism may be a genetic risk factor for heightened susceptibility to COVID-19. These findings demonstrate the potential of CLEC7A genotyping in predicting the course of disease and directing individualised treatment strategies. | ||||
| Keywords | ||||
| COVID‐19; cytokines; SARS‐CoV‐2; CLEC7A rs3901533 | ||||
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