PLGA Nanoparticles: A Next-Generation Approach for Dual-Drug Delivery Systems

Abdullah, Hend Diaa; Ramadan, Abd Elhakim; Gamal, Rawda Mofed; Fekry, Youmna Mohamed; Awad, Asmaa Hesham; Abo Mosalam, Amira Alaa; Aboelnoor, Eman Hassan; Helmy, Aya Essam; Omar, Aya Mohamed; El Sharbatly, Basant Nageb; Elrous, Tasneem Sherif; Kishta, Dina Elmorsy; Elserwy, Sohila Elsayed; Saleh, Shrouk Atya; Kamal, Madonna Magdy; Ramzy, Mariana Osama; Elgabas, Nada Tarek; El Menyawy, Nermeen Mohamed; Elfaramawy, Noura Aly; Abohadid, Mariam Essam; Abdo Elesh, Nada Elsayed; Elsayed, Yara Aly; Lasheen, Yassmin Mohamed; Shawkat, Sara Mohamed; Anees, Yara Ehab; Kamal, Islam

doi:10.21608/odr.2025.390611.1055

Abdullah, H., Ramadan, A., Gamal, R., Fekry, Y., Awad, A., Abo Mosalam, A., Aboelnoor, E., Helmy, A., Omar, A., El Sharbatly, B., Elrous, T., Kishta, D., Elserwy, S., Saleh, S., Kamal, M., Ramzy, M., Elgabas, N., El Menyawy, N., Elfaramawy, N., Abohadid, M., Abdo Elesh, N., Elsayed, Y., Lasheen, Y., Shawkat, S., Anees, Y., Kamal, I. (2025). PLGA Nanoparticles: A Next-Generation Approach for Dual-Drug Delivery Systems. EKB Journal Management System, (), -. doi: 10.21608/odr.2025.390611.1055

Hend Diaa Abdullah; Abd Elhakim Ramadan; Rawda Mofed Gamal; Youmna Mohamed Fekry; Asmaa Hesham Awad; Amira Alaa Abo Mosalam; Eman Hassan Aboelnoor; Aya Essam Helmy; Aya Mohamed Omar; Basant Nageb El Sharbatly; Tasneem Sherif Elrous; Dina Elmorsy Kishta; Sohila Elsayed Elserwy; Shrouk Atya Saleh; Madonna Magdy Kamal; Mariana Osama Ramzy; Nada Tarek Elgabas; Nermeen Mohamed El Menyawy; Noura Aly Elfaramawy; Mariam Essam Abohadid; Nada Elsayed Abdo Elesh; Yara Aly Elsayed; Yassmin Mohamed Lasheen; Sara Mohamed Shawkat; Yara Ehab Anees; Islam Kamal. "PLGA Nanoparticles: A Next-Generation Approach for Dual-Drug Delivery Systems". EKB Journal Management System, , , 2025, -. doi: 10.21608/odr.2025.390611.1055

Abdullah, H., Ramadan, A., Gamal, R., Fekry, Y., Awad, A., Abo Mosalam, A., Aboelnoor, E., Helmy, A., Omar, A., El Sharbatly, B., Elrous, T., Kishta, D., Elserwy, S., Saleh, S., Kamal, M., Ramzy, M., Elgabas, N., El Menyawy, N., Elfaramawy, N., Abohadid, M., Abdo Elesh, N., Elsayed, Y., Lasheen, Y., Shawkat, S., Anees, Y., Kamal, I. (2025). 'PLGA Nanoparticles: A Next-Generation Approach for Dual-Drug Delivery Systems', EKB Journal Management System, (), pp. -. doi: 10.21608/odr.2025.390611.1055

Abdullah, H., Ramadan, A., Gamal, R., Fekry, Y., Awad, A., Abo Mosalam, A., Aboelnoor, E., Helmy, A., Omar, A., El Sharbatly, B., Elrous, T., Kishta, D., Elserwy, S., Saleh, S., Kamal, M., Ramzy, M., Elgabas, N., El Menyawy, N., Elfaramawy, N., Abohadid, M., Abdo Elesh, N., Elsayed, Y., Lasheen, Y., Shawkat, S., Anees, Y., Kamal, I. PLGA Nanoparticles: A Next-Generation Approach for Dual-Drug Delivery Systems. EKB Journal Management System, 2025; (): -. doi: 10.21608/odr.2025.390611.1055

	PLGA Nanoparticles: A Next-Generation Approach for Dual-Drug Delivery Systems
Octahedron Drug Research
Articles in Press, Accepted Manuscript, Available Online from 18 June 2025
Document Type: Review Articles
DOI: 10.21608/odr.2025.390611.1055
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Authors
Hend Diaa Abdullah ; Abd Elhakim Ramadan; Rawda Mofed Gamal; Youmna Mohamed Fekry; Asmaa Hesham Awad; Amira Alaa Abo Mosalam; Eman Hassan Aboelnoor; Aya Essam Helmy; Aya Mohamed Omar; Basant Nageb El Sharbatly; Tasneem Sherif Elrous; Dina Elmorsy Kishta; Sohila Elsayed Elserwy; Shrouk Atya Saleh; Madonna Magdy Kamal; Mariana Osama Ramzy; Nada Tarek Elgabas; Nermeen Mohamed El Menyawy; Noura Aly Elfaramawy; Mariam Essam Abohadid; Nada Elsayed Abdo Elesh; Yara Aly Elsayed; Yassmin Mohamed Lasheen; Sara Mohamed Shawkat; Yara Ehab Anees; Islam Kamal
23 December street
Abstract
Poly (lactic-co-glycolic acid) (PLGA) is a potential polymer for nanoparticle-mediated medication delivery and is an FDA-approved polymer used in several applications. It is distinguished by its biodegradability and biocompatibility, as well as its capacity to distribute drugs to target organs, hence reducing side effects. This review looks at how lactic acid and glycolic acid, the two building blocks of this polymer, can be changed to create different structures and properties, including how quickly they break down. Various preparation techniques are examined, including salting-out, emulsion evaporation, and nanoprecipitation. PLGA is a special type of polymer that is commonly used to deliver two different anticancer or antibacterial drugs at the same time (dual drug delivery system), which will have a synergistic effect and avoid the problem of multidrug resistance (MDR). In addition, they can deliver vaccines and gene therapies and manage respiratory tract conditions, such as asthma and chronic obstructive pulmonary disease (COPD). Drugs can reach their target cells through passive diffusion, active transport, or receptor-mediated endocytosis. However, some harmful effects may limit how well medicine can spread; therefore, more research and careful changes to factors like size and surface charge are important to improve delivery and reduce adverse effects.
Keywords
Dual drug delivery systems; Poly-lactic-co-glycolic acid (PLGA) Nanoparticles; Biodegradable polymers; Cancer treatment; and Vaccine delivery


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