The demographic and biochemical data in polycystic Ovary Syndrome with and without Metabolic Associated Fatty Liver Disease. | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 19 June 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2025.391935.1976 | ||
| Authors | ||
| Taha Mohammad Hassanin1; Shereen R Mahmoud2; Mohamed Salah Abdelhamed3; Manar M. Sayed4; Selwan M khalf* 5; Nady M Semeda6 | ||
| 1Associate Prof. Endemic Medicine Depart. Faculty of Medicine | ||
| 2Internal Medicine Department ,Faculty of Medicine ,Minia University | ||
| 3Department of obstetrics & Gynecology, Faculty of Medicine, Minia University, Egypt | ||
| 4Radiology Department , Faculty of Medicine, Minia University, Egypt | ||
| 5Gastroenterology, hepatology and Tropical MedicineDepartment, Faculty of Medicine, Minia University | ||
| 6Tropical department,faculty of medecine, minya university | ||
| Abstract | ||
| Background & Aim Of The Study: The Metabolic Associated Fatty Liver Disease (MAFLD) is a common liver disease linked to insulin resistance and hormonal imbalances, especially in women with polycystic ovarian syndrome (PCOs).The aim of this work was to demonstrate the association between MAFLD and PCOs using demographic and biochemical data. Methods: This cross-sectional study was carried out on 80 female patients aged from 18 to 45 years old with clinical criteria of PCOs, who attended the gynecological and obstetrics outpatient clinics at Minya University Hospital. All patients underwent medical history, clinical examination, anthropometric measurements, laboratory investigations, all Patients were divided into two groups according to criteria of MAFLD: Group A: 45 PCOs patients with MAFLD and group B: 35 PCOs without MAFLD. Results: Group A had significantly higher BMI values, waist circumference, and hip circumference compared to those group B. However,no statistically significant differences were found in age, prediabetes prevalence, or hypertension. In blood picture and standard biochemical parameters,no significant differences were found between the two groups. When comparing non-invasive diagnostic scores, only the FIB-4 score showed a statistically significant difference between groups (p=0.049). Univariate logistic regression analysis identified several parameters significantly associated with MAFLD, including BMI, hip circumference, AST, postprandial glucose, FIB-4. several parameters significantly associated with MAFLD, including BMI, hip circumference, AST,postprandial glucose. Conclusions: Among all clinical, biochemical, and hormonal variables analyzed, supports the role of metabolic dysfunction in hepatic involvement among PCOS patients, reinforcing the importance of integrated metabolic and liver health screening in this population. | ||
| Keywords | ||
| Metabolic Associated Fatty Liver Disease; polycystic ovarian syndrome; Estrone | ||
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