Sensitivity and Specificity of Symptoms and Signs of CNS Infection in Children below 3 Years | ||||
| Aswan University Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 19 June 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aumj.2025.359938.1192 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Leila Youssef Mohamed  1; Mohamed bahaa elamir howary2; Khaled Abdelhai mohamed2
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| 1Pediatric department aswan univeristy | ||||
| 2Aswan University hospital | ||||
| Abstract | ||||
| Background: CNS infection is connected with numerous consequences including long-term complications and short-term complications. The most common symptom of CNS infection: fever, seizures, altered consciousness, and meningeal signs carries good predictive power. Objectives: This study aimed to explore the overall validity of the symptoms and signs of CNS infection in children aged three years or below. Methodology: This cross-sectional study was conducted on 100 children presented to Aswan University Hospital with clinical suspicion of CNS infection during the period from May 2023 till April 2024. Results: The median age was 8.5 months and 53% were males. Fever was present in 72%, lethargy in 76%, convulsion in 71%. As well, projectile vomiting was recorded in 53%, bulging fontanelle in 36%, 54% had neck stiffness and 45% had irritability. CSF culture was positive in 6% and blood culture in 27%. Morning headache, photophobia, and squint had better specificities and accuracies in detecting CNS infection. Conclusion: this study sheds light on the laboratory and clinical traits in children admitted with a range of CNS infection symptoms. Squint, photophobia, and morning headache, all showed promise as precise and specific markers of CNS illness. | ||||
| Keywords | ||||
| CNS Infection; Neurological Symptoms and Signs; Culture; Sensitivity; Specificity | ||||
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