Correlation Between Diffusion-Weighted MRI and Metabolic PET/CT Parameters in Patients with Pancreatic Cancer | ||
| International Journal of Medical Arts | ||
| Articles in Press, Accepted Manuscript, Available Online from 19 June 2025 PDF (1.38 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2025.382114.2179 | ||
| Authors | ||
| Heba Abdelhalim; Aya Yosry* ; Mohamed Mohamed Houseni; Mohamed Alwarraky | ||
| Department of Diagnostic and Interventional Radiology, National Liver Institute, Menoufia University, Shebin-Elkom, Menoufia, Egypt. | ||
| Abstract | ||
| Background: Pancreatic cancer's morbidity and mortality rates have been rising annually in recent years. Assessment of morphology and metabolic activity of pancreatic lesions using maximum standardized uptake value [SUVmax] has been made possible by the rapid progress of positron emission tomography/computed tomography [PET/CT]. Aim of the work: This study aimed to evaluate the correlation between the mean ADC value of diffusion weighted MRI and SUVmax of 18F-FDG PET/CT in pancreatic cancer. Patients and methods: The study included 30 individuals with histologically confirmed pancreatic adenocarcinoma. MRI DWI and 18F-FDG PET/CT were performed on each subject. ROI was applied over the pancreatic lesion to get the SUVmax and ADCmean values. Then the agreement between two values was studied. Additionally, we examined the efficacy of employing SUVmax > liver uptake as a diagnostic tool and assessed how DWMRI and PET/CT characteristics work together to improve diagnosis. Results: When the ADC value is less than 1.3x10-3, pancreatic cancer can be diagnosed with 83.33% sensitivity and 83.33% accuracy. Pancreatic lesions with SUVmax > liver activity can diagnose pancreatic cancer with 90% Sensitivity and 90% Accuracy. Combination of DW MRI and PET/CT parameters improved pancreatic cancer detection with 93.33% Sensitivity and 93.33% Accuracy. There was a moderate agreement between ADCmean and SUVmax in diagnosis of pancreatic cancer [kappa =0.429]. ADC pancreatic lesion/normal pancreatic parenchyma ratio can diagnose pancreatic cancer at cut off ≤0.69 [AUC =0.856] with 88.00 % sensitivity, 80.00% Specificity, 95.7% PPV and 57.1% NPV. There was a negative correlation between ADCmean and SUVmax of the pancreatic lesions [r=-0.491, P =0.005]. Conclusion: ADC values negatively correlated with SUVmax in pancreatic cancer. SUVmax and ADC values can diagnose pancreatic cancer with 90% and 83.33% accuracy receptively. Higher sensitivity and accuracy [93.33%] of combined DWMRI and18F-FDG PET/CT reinforce the complementary value of both methods in tumor assessment. | ||
| Keywords | ||
| Agreement; Correlation; 18FDG PET/CT-DW-MRI; Pancreatic cancer; SUVmax | ||
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