Correlation Between Diffusion-Weighted MRI and Metabolic PET/CT Parameters in Patients with Pancreatic Cancer | ||||
| International Journal of Medical Arts | ||||
| Articles in Press, Accepted Manuscript, Available Online from 19 June 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2025.382114.2179 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Heba Abdelhalim; Aya Yosry  ; Mohamed Mohamed Houseni; Mohamed Alwarraky
| ||||
| Interventional and Diagnostic Radiology Department, National Liver Institute, Menoufia University, shebin elkom, Menoufia, Egypt | ||||
| Abstract | ||||
| Background: Pancreatic cancer's morbidity and mortality rates have been rising annually in recent years. A comprehensive assessment of the morphology and metabolic activity of pancreatic lesions with quantitative assessment using maximum standardized uptake value (SUVmax) has been made possible by the rapid progress of positron emission tomography/computed tomography (PET/CT). Aim of the study: to evaluate the correlation between the mean ADC value of diffusion weighted MRI and SUVmax of 18F-FDG PET/CT in pancreatic cancer patients. Patients and Methods: a prospective research included 30 individuals with histologically confirmed pancreatic adenocarcinoma. MRI DWI and 18F-FDG PET/CT were performed on each subject. ROI was applied over the pancreatic lesion to get the SUV max and ADC mean value. We investigated whether 1.3X10-3 is a reliable cutoff value for pancreatic cancer diagnosis.. We examined how well the SUV max of pancreatic cancer lesions and the ADC mean value agreed. Additionally, we examined the efficacy of employing SUV max greater than liver uptake as a pancreatic cancer diagnostic tool and assessed how DW MRI and PET/CT characteristics work together to improve pancreatic cancer diagnosis. Results: When the ADC value is less than 1.3x10-3, pancreatic cancer can be diagnosed with 83.33% sensitivity and 83.33% accuracy. Combination of DW MRI and PET/CT parameters is improving pancreatic cancer detection with 93.33% Sensitivity and 93.33% Accuracy. ADC pancreatic lesion/normal pancreatic parenchyma ratio can diagnose pancreatic cancer at cut off ≤0.69 (AUC =0.856 and P value=0.006) with 88.00 % sensitivity, 80.00 % Specificity, 95.7 % PPV and 57.1% NPV. Conclusion: there was a significant negative correlation between ADC values from DW MRI and SUVmax from 18F-FDG PET/CT in pancreatic cancer. We detected moderate agreement (kappa=0.429) and strong diagnostic performance of ADC pancreatic cancer/normal pancreatic parenchyma ratio (cutoff ≤0.69, AUC = 0.856). | ||||
| Keywords | ||||
| Pancreatic cancer; MRI; SUVmax; Correlation. | ||||
|
Statistics Article View: 37 |
||||
