An Overview of Polymeric Nanoparticles-Based Drug Delivery System | ||
| Octahedron Drug Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 20 June 2025 | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/odr.2025.388713.1054 | ||
| Authors | ||
| Abd Elhakim Ramadan; Hend Diaa Abdullah* ; Rawda Mofed Gamal; Raneem Elsayed Elkeky; Sara Ahmed Ghoniem; Ola Emad Elawdy; Marwa Reda Ali; Yara Ali Noaaman; Maryam Farag Abdullah; Rawan Saad Abdelhady; Reham Mohsen Elalawy; Nagwa lbrahim Nasr; Menna Allah Mohamed Ibrahim; Menna Allah Samir Abo Almaaty; Hend Mounir Shalata; Basmala Emad ElKaref; Esraa Nasser Sanad; Manar Mahmoud Mohamed; Mariam Hany Nasr; Ali Hesham Mohamed; Yomna Mohamed Mansour; Asmaa Hesham Lotfy; Nada Elsayed Sobh; Islam Kamal | ||
| 23 December street | ||
| Abstract | ||
| Nanoparticulate drug delivery systems (NDDS) have attracted considerable interest in pharmaceutical sciences due to their capacity to improve medication bioavailability and facilitate targeted distribution. Their potential to encapsulate, safeguard sensitive drugs, and release therapeutic substances in a targeted manner has garnered considerable interest across various medical disciplines. Polymeric nanoparticles (PNPs) represent a category of innovative drug delivery systems that can be synthesized from either natural or synthetic polymers, yielding diverse structures such as dendrimers, polymeric micelles, polymer nanospheres, polymer nanocapsules, and polymersomes. The physicochemical characteristics of polymeric nanoparticles, such as dimensions, morphology, surface charge, and hydrophobicity, are crucial in determining their distribution, cellular absorption, and pharmacokinetics of drug release. PNPs can be designed for precise distribution, therefore reducing side effects and improving therapeutic efficacy. In comparison to conventional carriers, PNPs provide more stability and versatility. Their nanoscale dimensions facilitate cellular uptake and permit these particles to pass through biological barriers, including the blood-brain barrier. A significant advantage of employing these nanoparticles in therapy is their remarkable adaptability for surface modifications to enhance their anti-cancer efficacy. Numerous approved PNPs have been developed, offering harmless and biocompatible medication delivery techniques. Despite the significant promise of PNP alterations for drug delivery, numerous challenges remain to be addressed. The advancement of medication delivery by polymeric nanoparticles relies on our ability to model these complex interactions appropriately. | ||
| Keywords | ||
| Polymeric nanoparticles; Surface modification; Targeted delivery; Stability; Toxicity | ||
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