Aluminum oxide nanoparticles (Al₂O₃-NPs) toxicity in Sprague-Dawley rats: Clinico-Pathological & Biochemical Investigations. | ||||
| Damanhour Journal of Veterinary Sciences | ||||
| Article 2, Volume 13, Issue 1, February 2025, Page 11-26 PDF (964.96 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/djvs.2025.343949.1144 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Dina A Mahrous1; Amira E. Shehata2; Mariem K Sahgat3; Rania A Hamada4; Dalia Habashy Samak 5; Wael M Goda6; Shahenaz Mohamed Hassan  7
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| 1Clinical Pathology Department, Faculty of Veterinary Medicine, Damanhour University. Damanhour, Egypt | ||||
| 2Pathology department. Faculty of Veterinary Medicine. Damanhour University, Damanhour, Egypt. | ||||
| 3Toxicology and Forensic Medicine department. Faculty of Veterinary Medicine. Damanhour University, Damanhour, Egypt. | ||||
| 4Clinical Pathology Department, Faculty of Veterinary Medicine, Damanhur University, Damanhour, Egypt | ||||
| 5ِAssistant professor at Veterinary Forensic Medicine and Toxicology,Damanhour university | ||||
| 6Clinical Pathology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt. | ||||
| 7Agricultur Reasesrch Center (ARC), Animal Health Reasearch Institue (AHRI), Alexanderia Regional Laboratory , Alexanderia , Egypt. | ||||
| Abstract | ||||
| Aluminum oxide nanoparticles (Al₂O₃-NPs) are one of the most commonly used nanoparticles in nanotechnology that have a negative impact on the environment and health. Concerns are raised by the rapidly expanding usage of Al₂O₃-NPs in a range of industries, such as packaging materials, cutting tools, bone substitutes, and drug delivery systems. The handling and use of aluminum oxide nanoparticles should nevertheless be approached with caution due to the fact that exposure to these nanoparticles might result in oxidative stress, inflammation, genotoxicity, and cytotoxicity. Our study carried out 30 adult Sprague-Dawley male rats, divided into three groups: a control group, an Al₂O₃-L group (15 mg/kg bwt), and an Al₂O₃-H group (30 mg/kg bwt). Al₂O₃-NPs were administered i/p day after day for 8 weeks. The study found that rats exposed to Al₂O₃-NPs demonstrated mild anemia, reduced platelet counts, and an increase in white blood cells. Hepatic leakage enzymatic activities and creatinine levels were markedly increased in the Al₂O₃-H group. The Al₂O₃-H group's serum iron levels dramatically decreased. Malondialdehyde and nitric oxide levels were significantly (P ≤0.05) elevated in the liver and renal tissues. The Al₂O₃-H group displayed more possible negative consequences with significantly (P ≤0.05) elevated mRNA gene expression of Bax, IL-6, and TNFα in liver and kidney tissues, respectively. This study aimed to reveal the toxicological effect of Al₂O₃-NPs in vivo by using various clinicopathological investigations. | ||||
| Keywords | ||||
| Oxidative stress; Al₂O₃-NPs Toxicity; Clinicopathological studies; Biochemical studies | ||||
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