Histopathological evaluation of Nd: YAG laser versus Tuberculin Purified Protein Derivative in treatment of palmoplantar warts. | ||||
| Journal of Laser Science and Applications | ||||
| Article 4, Volume 2, Issue 1, June 2025, Page 101-106 PDF (716.23 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jlsa.2025.364275.1031 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Noha S Hanafy  1; Rasha Eladel2; Manal Salah3; Mahmoud Fawzi AbdelHamid4; Riham Nabil Ashoush5; Noha AbdAllah Gohdan6; Mohamed Mohsen Soliman7
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| 1National research centre | ||||
| 2Assistant researcher of Dermatology, Department of Dermatology and Venereology, Medical Research and Clinical Studies Institute, National Research Centre, NRC. | ||||
| 3Medical Applications of laser Dept., National Institute of Laser Enhanced Sciences, Cairo University. Egypt. | ||||
| 4Professor of Dermatology, Department of Dermatology and Venereology, Medical Research and Clinical Studies Institute, National Research Centre, NRC. Giza, Egypt. | ||||
| 5Researcher of Dermatology, Department of Dermatology and Venereology, Medical Research and Clinical Studies Institute, National Research Centre, NRC. Egypt. | ||||
| 6Lecturer, Department of Medical Applications of Laser, Dermatology Unit, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt | ||||
| 7Associate Professor of Dermatology, Department of medical applications of Laser, National Institute of Laser Enhanced Sciences, (NILES).Egypt. | ||||
| Abstract | ||||
| Background Warts, caused by HPV, exhibit hyperkeratosis, papillomatosis, and Koilocytes histopathologically. Nd: YAG laser provides photothermal destruction, while PPD offers an immunotherapeutic approach for treating palmoplantar warts. Purpose: To compare the histopathological effects of Nd: YAG laser monotherapy versus Tuberculin PPD in treating palmoplantar warts. Methods: Sixteen patients were divided into two groups: one received Nd: YAG laser sessions every 4 weeks (4 sessions), while the other received intralesional PPD every 2 weeks (6 sessions). Biopsies were taken before and after treatment (4 months). Histopathological analysis was performed using H&E and p16 immunohistochemistry. Results: In the Nd: YAG group, koilocyte count significantly decreased from 142.67±55.4 to 24.5±42.1 (p < 0.028), whereas PPD treatment showed a nonsignificant reduction (143.5±50.2 to 130.3±80.0, p = 0.753). Rete ridge elongation significantly reduced in the Nd: YAG group (17.83±6.6 to 8.17±8.8, p < 0.027) but not in the PPD group (p = 0.115). p16 expression also significantly decreased with Nd: YAG (54.39±4.6 to 13.9±16.4, p = 0.028), while PPD had a nonsignificant effect. Conclusion: Nd: YAG laser was more effective than PPD in reducing koilocytes, rete ridges, and p16 expression. | ||||
| Keywords | ||||
| p16; palmoplantar warts; Tuberculin PPD; Nd: YAG Laser; Koilocytes | ||||
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