Crocin mitigates liver Impairment in diabetic rats by Upregulation of Nrf2/HO-1 signaling pathway | ||||
| Medicine Updates | ||||
| Articles in Press, Accepted Manuscript, Available Online from 23 June 2025 PDF (1.08 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/muj.2025.380818.1227 | ||||
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| Authors | ||||
Shimaa Fouad1; Suzan A Khodir   2; Mohamed Shebl Amer3; Noha Abd El-aziz4; Ramy A Abdelsalam5; Walaa M Elgheriany6; Mai A Ebeid7; Reem Mohammed Ahmed8; Heba Abdelrazak Abdelfatah9; Reem M Emam10
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| 1Medical physiology Department, Faculty of Medicine for girls, Al Azhar University, Cairo, Egypt. | ||||
| 2Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt. | ||||
| 3Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||||
| 4Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||||
| 5Pathology Department, Faculty of Medicine, Mansoura University, Egypt | ||||
| 6Haematology Unit, Internal Medicine Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||||
| 7Clinical Pharmacology Department, Faculty of Medicine, Ain Shams University, Egypt. | ||||
| 8Medical Biochemistry and Molecular Biology Department Faculty of Medicine (Girls), Al-Azhar University | ||||
| 9Histology Department, Faculty of Medicine, Helwan University Egypt | ||||
| 10Medical Physiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||||
| Abstract | ||||
| Background: The most prevalent kind of diabetes is type 2 diabetes mellitus. Chronic liver damage is a problem that frequently accompanies diabetes mellitus. Crocin is believed to possess antioxidant and anti-inflammatory properties. Objective: to demonstrate the potential underlying processes and hepatoprotective impact of Crocin in DM. Material and methods: Diabetic, Diabetic+Crocin, and control (10/group) were the three groups into which thirty male albino rats were divided. Assessments were made of the following: The measured serum glucose, serum insulin, HOMA-IR index, serum glycosylated Hb A1c, serum lipids, serum liver enzymes, hepatic MDA, hepatic SOD, hepatic TNF-α, hepatic IL-6, hepatic IL-10, hepatic Nrf2 gene expression and hepatic HO-1 gene expression. Furthermore, histological and immunohistochemical examinations of the liver were carried out. Results: The measured serum glucose, serum insulin, HOMA-IR index, serum glycosylated Hb A1c, serum cholesterol, serum triglyceride, serum ALT, serum AST, serum ALP, serum GGT, hepatic MDA, hepatic TNF-α and hepatic IL-6 were all markedly raised in Diabetic group compared to control, while the Diabetic 's hepatic SOD, hepatic IL-10 and hepatic gene expression of Nrf2 and HO-1 were substantially lower than control group. Additionally there was dramatically downregulated hepatic NF-kB and caspase-3 immunoreaction of Diabetic group compared to control. Crocin significantly mitigated diabetic induced hepatic changes. Conclusion: By upregulating the hepatic Nrf2/HO-1 signaling pathway and exhibiting lipid-lowering, anti-inflammatory, antiapoptotic, and antioxidant properties, crocin guards against diabetes-induced liver damage | ||||
| Keywords | ||||
| Crocin; Diabetis Mellitus; HO-1; Liver NF-kB; Nrf2 | ||||
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