Luteolin mitigates deoxycorticosterone acetate-salt-induced hypertension in rats by activation of Nrf2/HO-1 pathway | ||
| Medicine Updates | ||
| Articles in Press, Accepted Manuscript, Available Online from 23 June 2025 PDF (799.01 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/muj.2025.386368.1226 | ||
| Authors | ||
| Shorouk E. M. Elmorshdy1; Suzan A Khodir* 2; Noha M. Abd El-aziz3; Aya Yousri Abu-zeid4; Mohamed Osama Megahed5; Mai A. Ebeid6; Mai A. H. Abouelenin7; Shaimaa Mohammed Zaher8; Mohamed A. Abdelhameed9; Samar M. Hussein10; Rania Salah Mansour11 | ||
| 1Medical Physiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||
| 2Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt. | ||
| 3Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 4Pathology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 5Internal Medicine Department, Nephrology Unit, Faculty of Medicine, Damietta University, Egypt | ||
| 6Clinical Pharmacology Department, Faculty of Medicine, Ain Shams University, Egypt | ||
| 7Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt | ||
| 8Histology and Cytology Department, Faculty of Medicine, Helwan University, Egypt | ||
| 9Cardiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt. | ||
| 10Medical Physiology Department, Faculty of Medicine, Suez Canal University, Egypt | ||
| 11Medical Physiology Department, Faculty of Medicine, Ain Shams University, Egypt. | ||
| Abstract | ||
| Background: One of the risk factors for vascular disorders is hypertension. Several characteristics of human hypertension are replicated in the deoxycorticosterone acetate (DOCA) salt rat model. A common flavonoid having anti-oxidant and anti-inflammatory impacts is luteolin (lut). Aim of the study: to illustrate Lut's vascular protective effect and its underlying mechanisms in DOCA-induced hypertension. Material and methods: Thirty male albino rats were split into three: DOCA, DOCA+Lut, and control (10/group). Rats underwent ABP evaluation in addition to measurements of aortic gene expression of Nrf2 and HO-1, serum cholesterol, serum triglycerides, aortic MDA, aortic SOD, aortic TNF-α, aortic IL-6, and aortic IL-10. Aortic immunohistochemical and histological studies were also carried out. Results: Aortic SOD and aortic gene expression of Nrf2 and HO-1 values were dramatically decreased in the DOCA than in the control, but the measured SBP, DBP, MABP, serum levels of cholesterol and triglycerides, aortic MDA, aortic TNF-α, and aortic IL-6 were all dramatically increased in the DOCA than in the control. In addition, DOCA's immunoreactivity to Caspase-3 and aortic NF-kB was higher than that of the control. Lut significantly reduced the vascular alterations brought on by DOCA. Conclusion: By upregulating the Nrf2/HO-1 signaling pathway and having anti-inflammatory, anti-apoptotic, and antioxidant effects, luteoin has a vascular-protective effect in DOCA-induced hypertension. | ||
| Keywords | ||
| DOCA HO-1; Luteolin NF-kB; Nrf2 Vasculopathy | ||
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