Albiflorin mitigates diabetic nephropathy in rats by down-regulation of TLR4/NF-kB signaling pathway | ||
| Medicine Updates | ||
| Articles in Press, Accepted Manuscript, Available Online from 24 June 2025 PDF (1.18 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/muj.2025.391322.1229 | ||
| Authors | ||
| Samar M. Hussein1; Suzan A Khodir* 2; Ghada S Amer3; Noha Abd El-aziz4; Aya Yousri Abu-zeid5; Aly Mohamed Elkholy6; Maha Tarek Mohammed7; Mai A. H. Abouelenin8; Heba Abdelrazak Abdelfatah9; Esraa A Elnahrawy10 | ||
| 1Medical Physiology Department, Faculty of Medicine, Suez Canal University, Egypt | ||
| 2Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt. | ||
| 3Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 4Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 5Pathology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 6Internal Medicine Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 7Clinical Pharmacology Department, Faculty of Medicine, Ain Shams University, Egypt | ||
| 8Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt | ||
| 9Histology Department, Faculty of Medicine, Helwan University Egypt | ||
| 10Physiology Department, Badr University in Cairo (BUC), Cairo, Egypt. | ||
| Abstract | ||
| Introduction: Diabetic nephropathy (DN) is severe medical condition. It has been shown that albiflorin (ALB) has potent pharmacological effects in preventing oxidation, inflammation, and apoptosis. Objective: to evaluate the possible underlying mechanisms and the protective effect of ALB in STZ-induced DN. Materials and Methods: There were three groups of thirty adult male albino rats: control, DN, and DN+ALB (10/group). blood levels of glucose, glycosylated Hb A1c, cholesterol, triglycerides, urea, creatinine, renal SOD, creatinine clearance, renal MDA, renal TNF-α, renal IL-6, and renal genes expression of TLR4 and NF-kB. Additionally, immunohistochemical and renal histopathology analyses were carried out. Results: Serum levels of glucose, glycosylated Hb A1c, cholesterol, triglycerides, urea, and creatinine were significantly elevated in conjunction with urine albumin, renal MDA, renal TNF-α, renal IL-6, and renal genes TLR4 and NF-kB expression of DN in comparison to the control. It also significantly decreased creatinine clearance values and renal SOD expression. Furthermore, compared to the control, the DN group's TLR4 and NF-kB immunoreactions were both increased. The STZ-induced DN alterations significantly improved in the DN+ALB group. Conclusion: ALB offers substantial protection against STZ-induced DN through hypoglycemic, anti-oxidant and anti-inflammatory mechanisms as well as the down-regulation of TLR4/NF-kB signaling pathway. | ||
| Keywords | ||
| Albiflorin; Diabetic Nephropathy; NF-kB; TLR4 | ||
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