Relation of Cholecystokinin B Receptor Gene Polymorphisms in Helicobacter Pylori Patients With and Without Hepatitis C Virus
Badr, E., Tahoun, A., El Sayed, I., El Boraey, H., Nagy, A. (2025). Relation of Cholecystokinin B Receptor Gene Polymorphisms in Helicobacter Pylori Patients With and Without Hepatitis C Virus. EKB Journal Management System, (), -. doi: 10.21608/ejchem.2025.354980.11204
Eman Badr; Alaa Tahoun; Ibrahim El Sayed; Hanaa El Boraey; Alaa Osama Nagy. "Relation of Cholecystokinin B Receptor Gene Polymorphisms in Helicobacter Pylori Patients With and Without Hepatitis C Virus". EKB Journal Management System, , , 2025, -. doi: 10.21608/ejchem.2025.354980.11204
Badr, E., Tahoun, A., El Sayed, I., El Boraey, H., Nagy, A. (2025). 'Relation of Cholecystokinin B Receptor Gene Polymorphisms in Helicobacter Pylori Patients With and Without Hepatitis C Virus', EKB Journal Management System, (), pp. -. doi: 10.21608/ejchem.2025.354980.11204
Badr, E., Tahoun, A., El Sayed, I., El Boraey, H., Nagy, A. Relation of Cholecystokinin B Receptor Gene Polymorphisms in Helicobacter Pylori Patients With and Without Hepatitis C Virus. EKB Journal Management System, 2025; (): -. doi: 10.21608/ejchem.2025.354980.11204

Relation of Cholecystokinin B Receptor Gene Polymorphisms in Helicobacter Pylori Patients With and Without Hepatitis C Virus

Egyptian Journal of Chemistry
Articles in Press, Accepted Manuscript, Available Online from 25 June 2025  XML
Document Type: Original Article
DOI: 10.21608/ejchem.2025.354980.11204
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Authors
Eman Badr1; Alaa Tahoun2; Ibrahim El Sayedorcid 3; Hanaa El Boraey2; Alaa Osama Nagy email 4
1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menofia university
2Chemistry Department, Faculty of Science, Menofia University, Egypt
3Chemistry Department, Faculty of Science, Menofia University, Shebin El Kom, Egypt
4Medical Biochemistery and Molecular Biology, Faculty of Medicine, Menofia university, Egypt
Abstract
Background: There is no doubt about the association between the cholecystokinin B receptor (CCKBR) gene and susceptibility to helicobacter pylori (H. pylori) infection. CCKBR gene encodes a G-protein-coupled receptor for gastrin and cholecystokinin (CCK). Several genetic studies have demonstrated an implication of CCK in the feedback control of gastrin release and gastric acid secretion in healthy subjects. Recent studies in patients infected with hepatitis C virus (HCV) refer to the bad effect of H. Pylori infection on the course of liver injury, especially extensive fibrosis.
Objectives: We aimed to investigate whether there is an association between the CCKBR (rs2929180 and rs1800843) single nucleotide polymorphisms (SNPs) and the susceptibility to H. pylori infection in patients with and without HCV.
Subjects and methods: This current work was carried out on 195 subjects. They were classified into three groups: Group I: 65 H. Pylori patients with HCV, Group II: 65 H. Pylori patients without HCV, and 65 age- and gender-matched healthy controls. All subjects underwent genotyping of CCKBR (rs2929180 and rs1800843) by real-time PCR.
Results: The frequency of T/T in CCKBR (rs2929180) was higher in H. Pylori patients with HCV than in H. Pylori patients without HCV and controls (23.1% vs. 7.7% and 0%). The frequency of the C/C and C/A of CCKBR (rs1800843) was higher in H. Pylori patients with HCV than in H. Pylori patients without HCV and controls (13.8% vs. 4.6% and 1.5%) and (32.3% vs. 20% and 12.3%) respectively.
Conclusion: CCKBR (rs2929180 and rs1800843) gene polymorphisms may play a role in determining the degree of H. Pylori infection and HCV severity.
Keywords
H. pylori; HCV; CCKBR
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