Interleukin-36 Level in Patients with Vitiligo: A Systematic Review… | ||||
| Fayoum University Medical Journal | ||||
| Volume 15, Issue 2, June 2025, Page 33-46 PDF (777.13 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/fumj.2025.336620.1426 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Marwa Gamal Hassen  1; Samar Mohamed El Tahlawy2; Olfat Gamil Shaker3; Mohammed Hassan Mohammed4
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| 1Dermatology Department,Faculty of medicine,Fayoum university | ||||
| 2Dermatology, Faculty of Medicine, Cario Universityayoum University | ||||
| 3Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo | ||||
| 4Dermatology , STDs and Andrology , Faculty of Medicine , Fayoum University, Fayoum,Egypt | ||||
| Abstract | ||||
| Background: Research on the role of interleukin-36 in vitiligo, a chronic autoimmune skin ailment characterized by skin depigmentation caused by melanocyte loss, is rather restricted when compared to other autoimmune skin conditions such as psoriasis. Objective: to evaluate the role of the interleukin-1 family, especially interleukin-36 in the pathogenesis of vitiligo. Material and Methods: We searched Cochrane, Web of Science, PubMed, and SCOPUS for relevant articles. We utilized a strategy for our search by combining these keywords: ('' interleukin-1 '' OR '' interleukin-1 '' OR '' interleukin-36 '' OR '' interleukin-36 '') AND ('' pigmentary skin disorder '' OR '' vitiligo '' OR '' autoimmune disorder '' OR '' depigmenting disorder ''). Quality assessment of the involved studies was evaluated according to Cochrane’s risk of bias tool. Results: we found that the levels of tissues and serum interleukin-36 are elevated significantly in lesional skin and non-lesional skin of patients suffering from vitiligo. Additionally, Family members of interleukin-1 such as interleukin-36, interleukin-33, interleukin-1α, and interleukin-18 have a substantial impact on the pathogenesis of vitiligo. Conclusion: Family members of interleukin-1 such as interleukin-36, interleukin-33, interleukin-1α, and interleukin-18 have a substantial impact on the pathogenesis of vitiligo. Interleukin-36 has an important impact on the etiology of vitiligo due to its powerful pro-inflammatory effects. It is strongly connected with the severity of the disease and is more present in the tissue and serum of individuals suffering from vitiligo than in healthy people. | ||||
| Keywords | ||||
| Interleukin-1; Interleukin-36; vitiligo; autoimmune disorder; depigmenting disorder | ||||
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