Osteocalcin Level in Children with Nephrotic Syndrome: A Systematic Review | ||||
| Fayoum University Medical Journal | ||||
| Volume 15, Issue 2, June 2025, Page 60-69 PDF (767.58 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/fumj.2025.328132.1407 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ghada Amin Osman  1; Sherin Khamis Hussein2; Ashraf Sayed Kamel3; Doaa Younis Ali4
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| 1Department of Pediatrics , Fayoum General Hospital,Fayoum, Egypt | ||||
| 2Pediatric Department, Faculty of Medicine, Fayoum University,Fayoum, Egypt | ||||
| 3Pediatric department , Faculty of medicine , Fayoum university , Fayoum , Egypt | ||||
| 4Department of clinical pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt | ||||
| Abstract | ||||
| Background Osteocalcin (OC) is a protein hormone that is improtant in bone metabolism. OC levels have been impacted in children exhibit nephrotic syndrome (NS), which is defined by inflammation and protein loss in urine. Methods I conducted a systematic examination to assess the serum osteocalcin (S-OC) level in children with NS. This subset data consisted of 975 children. Results A review of 10 studies, which included 975 children, determined remission as the lack of albumin in three consecutive early morning urine samples (or proteinuria <4 mg/m2/h). A tolerance on steroids was detected by two consecutive relapses throughout alternate day steroid utilization or within 2 weeks of quitting steroids. Steroid Resistant NS is defined as the inability to achieve recovery after four weeks of medication with 2 mg/kg/day of prednisolone. Conclusion The increase in OC levels depends on the dosage of glucocorticoids given, not on the particular kind of GC prescribed. This could have importance in clinical and could help reduce bone-related side effects. When vitamin D supplementation is provided, the utilization of multiple courses of steroid therapy usually has no impact on height as a growth parameter. It is not recommended to utilize OC as a screening tool in children on steroids, as the rise in serum levels may occur due to either bone turnover or formation. | ||||
| Keywords | ||||
| Nephrotic Syndrome; Children, Osteocalcin | ||||
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