The Effect of Leaf Extracts (Hawthorn and Carica Papaya) and Their Combination on Insulin Resistance in Rats | ||
| المجلة العلمية لكلية التربية النوعية جامعة دمياط | ||
| Volume 2025, Issue 11, June 2025, Pages 259-286 PDF (1.5 M) | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/sjeud.2025.397557.1068 | ||
| Authors | ||
| رشا عرفة* 1; طلعت سحلول2; إيمان إبراهيم عبد الحليم إبراهيم3; هبة مصطفى الخولي2 | ||
| 1قسم الاقتصاد المنزلى ،كلية التربية النوعية ,جامعة دمياط | ||
| 2قسم الاقتصاد المنزلي - كلية التربية النوعية _ جامعة دمياط | ||
| 3- كلية التربية النوعية _ جامعة دمياط | ||
| Abstract | ||
| Hawthorn and papaya leaves are widely known for their therapeutic benefits and traditional use in treating infections, inflammation, and various health conditions. Given their abundance of bioactive compounds, this study aimed to investigate the potential effects of these leaf extracts and assess their possible applications in developing functional foods. Therefore, this study was conducted to evaluate the impact of aqueous extracts of (HLE) and (PLE) on feed intake, body weight gain%, organ weights relative body weight, markers of glucose metabolism and insulin resistance, liver enzyme activity, kidney functions, lipid profile, and antioxidant enzymes of rats with insulin resistance. . Simultaneous treatment of rats suffering from insulin resistance with two levels of aqueous extracts of Hawthorn and Carica Papaya and their combination along with fructose led to a decrease in feed intake, body weight gain%, and FER. A significant improvement in levels of fasting plasma glucose (FPG), fasting plasma insulin (FPI), HOMA-IR, HbA1C %, triglycerides, total cholesterol, low- and very low-density lipoprotein cholesterol, kidney functions (uric acid, urea nitrogen, and creatinine), liver enzyme activity (AST, ALT, and ALP), and MDA enzyme activity. The antioxidant enzyme activities (SOD, GPX, and CAT) and HDL-c rose in comparison to the PC. In addition, histological examination of the liver and pancreas of rats in groups treated with different levels of the H and P leaf extracts and their combination showed a noticeable improvement in the tissue structure of these organs. Sensory evaluation indicated that all cookie samples had an acceptance greater than 75%. | ||
| Keywords | ||
| Hawthorn; Papaya; Insulin Resistance | ||
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