Systemic Immune Inflammation Index: A Novel Predictor for Coronary Collateral Circulation in Patients with Stable Coronary Artery Disease | ||||
| Benha Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 28 June 2025 PDF (367.42 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2025.378708.2384 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mahmoud S. Abdelmoneum1; Khaled E. Elrabat2; Mohamed E. Abd-Ellatif  3; Hager I. Allam4
| ||||
| 1Assistant Professor of Cardiology, Faculty of Medicine, Benha University | ||||
| 2Professor of Cardiology, Faculty of Medicine, Benha University | ||||
| 3(M.B.B. Ch, Faculty of Medicine, Benha University, Resident of Cardiology, Benha University Hospitals) | ||||
| 4Lecturer of Cardiology, Faculty of Medicine, Benha University | ||||
| Abstract | ||||
| Background: Chronic Coronary Syndrome (CCS) causes increasing coronary artery blood flow limitation. A new inflammatory measure, the systemic immune-inflammation index (SII), may predict cancer treatment failure. This research examined how stable coronary artery disease (CAD) patients' CCD and SII connect. Methods: This single-center, cross-sectional research comprised 100 stable CAD patients. After that, patients were divided into two groups based on coronary collateral circulation: Group 1 had 78 healthy collaterals and Group 2 had 22 defective collaterals. We performed coronary angiography, transthoracic echocardiography, electrocardiography, and lab tests. The Rentrop classification system graded collateral vessels. Results: Patients with stable coronary artery disease (CAD) who had weak coronary collaterals were more likely to have SII, platelet, neutrophil, and lymphocyte levels, as well as laboratory indices like the Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and NLR. Then in the multivariant analysis, SII was found to be the only independent predictor of poor coronary collaterals in stable CAD patients underwent coronary angiography [95% CI: 1.0 – 1.014, P value < 0.05]. SII cutoff value of 1135.5 was shown to have the best diagnostic accuracy (sensitivity = 86.4%, specificity = 98.7% and area under curve = 0.893) in prediction of poor coronary collaterals in stable CAD patients underwent Coronary Angiography Conclusion: In damaged coronary collaterals, CRP, NLR, PLR, and SII were considerably greater. SII was the only independent predictor of CAD patients' compromised coronary collaterals. The SII cutoff value of 1135.5 best predicts weak coronary collaterals in chronic coronary syndrome patients. | ||||
| Keywords | ||||
| Predictor; Disease.Coronary Collateral Circulation; Systemic Immune Inflammation Index; Stable Coronary Artery | ||||
|
Statistics Article View: 51 PDF Download: 21 |
||||
