Recently Identified MicroRNAs as Potential Diagnostic and Prognostic Biomarkers in Acute coronary syndrome
Saeed, D., Rashwan, H., AbdElnasser, D., Ali, R., Yehia, H., Mohamed, R., AbdElsalam, R., Elsayed, S., Omar, N., Mohanad, M. (2025). Recently Identified MicroRNAs as Potential Diagnostic and Prognostic Biomarkers in Acute coronary syndrome. EKB Journal Management System, 2(2), 40-71. doi: 10.21608/jpsdm.2025.385792.1034
Doaa Fayez Saeed; Hager K. Rashwan; Doha AbdElnasser; Reham Ali; Hager Yehia; Reem Mohamed; Reham AbdElsalam; Sara Elsayed; Nada Mohamed Omar; Marwa Mohanad. "Recently Identified MicroRNAs as Potential Diagnostic and Prognostic Biomarkers in Acute coronary syndrome". EKB Journal Management System, 2, 2, 2025, 40-71. doi: 10.21608/jpsdm.2025.385792.1034
Saeed, D., Rashwan, H., AbdElnasser, D., Ali, R., Yehia, H., Mohamed, R., AbdElsalam, R., Elsayed, S., Omar, N., Mohanad, M. (2025). 'Recently Identified MicroRNAs as Potential Diagnostic and Prognostic Biomarkers in Acute coronary syndrome', EKB Journal Management System, 2(2), pp. 40-71. doi: 10.21608/jpsdm.2025.385792.1034
Saeed, D., Rashwan, H., AbdElnasser, D., Ali, R., Yehia, H., Mohamed, R., AbdElsalam, R., Elsayed, S., Omar, N., Mohanad, M. Recently Identified MicroRNAs as Potential Diagnostic and Prognostic Biomarkers in Acute coronary syndrome. EKB Journal Management System, 2025; 2(2): 40-71. doi: 10.21608/jpsdm.2025.385792.1034

Recently Identified MicroRNAs as Potential Diagnostic and Prognostic Biomarkers in Acute coronary syndrome

Journal of Pharmaceutical Sciences and Drug Manufacturing-Misr University for Science and Technology
Volume 2, Issue 2 - Serial Number 20225, June 2025, Page 40-71  XML PDF (869.65 K)
Document Type: Review Articles.
DOI: 10.21608/jpsdm.2025.385792.1034
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Authors
Doaa Fayez Saeed email orcid 1; Hager K. Rashwan1; Doha AbdElnasser2; Reham Ali2; Hager Yehia2; Reem Mohamed2; Reham AbdElsalam2; Sara Elsayed2; Nada Mohamed Omar1; Marwa Mohanad1
1Department of Biochemistry, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th October City, Giza, Egypt.
2College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt
Abstract
Background: Cardiovascular diseases (CVDs) remain the most prevalent cause of mortality globally. Acute coronary syndrome (ACS) is a category of CVDS with a high fatality rate. Thus, early diagnosis and effective management of ACS are crucial to improve patient outcomes. Biomarkers, which are measurable biological indicators, have emerged as essential tools for the diagnosis, prognosis, and risk stratification of ACS. Recently, small non-coding RNAs (miRs) have been found to affect messenger RNA (mRNA) stability by either suppressing their translation or promoting their degradation through complementary base pairing, thereby acting as negative regulators of protein translation. Moreover, miRs play a key role in regulating various signaling pathways and cellular functions, including intercellular communication. Aim and concept of review: Since miRs expression has been identified in the blood of patients with various cardiovascular conditions, they are regarded as promising noninvasive biomarkers. This study provides an overview of the existing literature on the role of miRs in ACS. Conclusion: The findings suggest that miRs could serve as potential diagnostic and prognostic biomarkers in ACS, and hence, miR regulation may offer new perspectives for therapeutic interventions in ACS.
Keywords
MicroRNAs; Biomarkers; Acute coronary syndrome; Acute myocardial infarction; Unstable angina pectoris
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