Evaluation of the Monocyte Chemotactic Protein-3 Gene (rs17735770) Polymorphism in patients with Type 2 Diabetes Mellitus | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 January 2026 | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.384132.1636 | ||
| Authors | ||
| Kawther B.B. Al-Noor* ; Abeer T.N. Al-Hasnawi | ||
| Department of Microbiology, Faculty of Medicine, Karbala University, Iraq | ||
| Abstract | ||
| Background: Type 2 diabetes mellitus (T2DM) is a chronic and complex metabolic disorder, typically resulting from the progressive failure of insulin to regulate blood glucose levels. The chemokine monocyte-chemotactic protein-3 (MCP-3) gene polymorphism plays an important role in the pathogenesis of T2DM, its involvement in inflammatory processes and vascular complications that cause damage to pancreatic cells. Objective: The objective of current study was to investigate the association between genetic variation of MCP-3 (rs17735770) and the progression of the disease. Methodology: A case-control study included 50 T2DM patients and 50 healthy controls. DNA was extracted from whole blood samples and used to recognize the MCP-3 gene (rs17735770) polymorphism using conventional polymerase chain reaction (PCR). Results: Concerning the MCP-3 genotypes, there were no statistical differences (P = 0.255) between the studied groups. In patients, the CC and TT frequency genotypes were increased, whereas the control group had a higher ''TC'' genotype frequency. Regarding allele frequency, the “C” allele was higher in patients. On the contrary, the “T” allele was elevated in the control group, with (P=0.390). Conclusion: The current study revealed that the ''CC'' genotype was increased in patients compared to controls. Therefore, the polymorphism of the MCP-3 gene (rs17735770) may represent a risk factor for T2DM. | ||
| Keywords | ||
| Type 2 diabetes mellitus; monocyte-chemotactic protein-3 gene; polymorphism; MCP-3; rs17735770 | ||
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