Evaluation of the Monocyte Chemotactic Protein-3 Gene (rs17735770) Polymorphism in patients with Type 2 Diabetes Mellitus | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Article 29, Volume 35, Issue 1, January 2026 | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
| DOI: 10.21608/ejmm.2025.384132.1636 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Kawther B.B. Al-Noor   ; Abeer T.N. Al-Hasnawi
| ||||
| Department of Microbiology, Faculty of Medicine, Karbala University, Iraq | ||||
| Abstract | ||||
| Background: Type 2 diabetes mellitus (T2DM) is a chronic and complex metabolic disorder, typically resulting from the progressive failure of insulin to regulate blood glucose levels. The chemokine monocyte-chemotactic protein-3 (MCP-3) gene polymorphism plays an important role in the pathogenesis of T2DM, its involvement in inflammatory processes and vascular complications that cause damage to pancreatic cells. Objective: The objective of current study was to investigate the association between genetic variation of MCP-3 (rs17735770) and the progression of the disease. Methodology: A case-control study included 50 T2DM patients and 50 healthy controls. DNA was extracted from whole blood samples and used to recognize the MCP-3 gene (rs17735770) polymorphism using conventional polymerase chain reaction (PCR). Results: Concerning the MCP-3 genotypes, there were no statistical differences (P = 0.255) between the studied groups. In patients, the CC and TT frequency genotypes were increased, whereas the control group had a higher ''TC'' genotype frequency. Regarding allele frequency, the “C” allele was higher in patients. On the contrary, the “T” allele was elevated in the control group, with (P=0.390). Conclusion: The current study revealed that the ''CC'' genotype was increased in patients compared to controls. Therefore, the polymorphism of the MCP-3 gene (rs17735770) may represent a risk factor for T2DM. | ||||
| Keywords | ||||
| Type 2 diabetes mellitus; monocyte-chemotactic protein-3 gene; polymorphism; MCP-3; rs17735770 | ||||
|
Statistics Article View: 60 |
||||
