EVALUATION OF THE ROLE OF CXCL12 IN CASES OF ALOPECIA AREATA | ||
| ALEXMED ePosters | ||
| Article 1, Volume 7, Issue 2, April 2025, Pages 69-70 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2025.394861.2191 | ||
| Authors | ||
| Wafaa Ibrahim Abdallah1; Eman Mohamed Eleryan2; Mona Moustafa Tahoun3; Israa Khaled Shaddad Zreid* 4 | ||
| 1Professor of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University. | ||
| 2Lecturer of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University | ||
| 3Department of Clinical and Chemical Pathology, Faculty of Medicine University of Alexandria. | ||
| 4Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University. | ||
| Abstract | ||
| Introduction Alopecia areata (AA) is a common immune-mediated disorder that targets anagen hair follicles and causes nonscarring hair loss. The condition most commonly presents with discrete patches of hair loss on the scalp. Other hair-bearing areas may also be affected. In severe cases, patients may experience loss of all scalp or body hair. Patients with alopecia areata typically have smooth, circular, discrete areas of complete hair loss that develop over a period of a few weeks. CXCL12expression during hair cycle progression have not been characterized. In alopecia areata, a few studies were done and observed different results about the role of CXCL12 in hair growth so it may play dual and complex role in the pathogenesis of alopecia areata. On one hand, CXCL12 contributes significantly to angiogenesis during adulthood by attracting bone marrow-derived endothelial progenitor cells via a CXCR4 dependent pathway. In AA, decreased CXCL12 levels may impair angiogenesis, potentially disrupting the vascular support of healthy hair follicle , thereby contributing to hair loss. On the other hand, CXCL12 is implicated in the autoimmune mechanisms of AA. Human dermal γδ T cells, known to act as stress sentinels, are recruited to stressed hair follicles through the overexpression of chemoattractants such as CXCL10 and CXCL12. This exacerbates the autoimmune attack on hair follicles, leading to hair loss. | ||
| Keywords | ||
| CXCL12; in Alopecia areata; Dermoscopic examination | ||
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