Dyslipidemia and Its Association with Microalbuminuria in Children and Adolescents with Type 1 Diabetes | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 19, Volume 100, Issue 1, July 2025, Page 2656-2660 PDF (491.21 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2025.436786 | ||||
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| Abstract | ||||
| Background: Type 1 diabetes mellitus (T1DM) is a chronic metabolic disorder that can lead to various complications, including diabetic nephropathy. Dyslipidemia is a common comorbidity in T1DM, and its role in the development and progression of microalbuminuria, an early marker of nephropathy, is of significant clinical interest. Objective: Was to investigate the association between dyslipidemia and microalbuminuria in children and adolescents with T1DM. Patients and Methods: A cross-sectional case-control study was conducted, including 60 children and adolescents with T1DM and 30 controls. Clinical and laboratory data were collected, including lipid profile, urinary albumin/creatinine ratio (A/C ratio), and other relevant parameters. Patients were divided into normo-albuminuric and microalbuminuric groups based on their A/C ratio. Statistical analyses were performed to compare the groups. Results: Children and adolescents with microalbuminuria demonstrated significantly higher levels of total cholesterol, triglycerides, and LDL cholesterol, and significantly lower levels of HDL cholesterol compared to both normo-albuminuric T1DM patients and healthy controls. Conclusion: Dyslipidemia is strongly associated with microalbuminuria in pediatric T1DM patients. These findings highlight the importance of early lipid management in this population to potentially prevent or delay the progression of diabetic nephropathy. | ||||
| Keywords | ||||
| T1DM; Microalbuminuria; Dyslipidemia; Diabetic nephropathy; Children; Adolescents | ||||
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