The detrimental impact of smoking on osteoporosis: A narrative review | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Volume 34, Issue 1, July 2025, Pages 1-8 PDF (347.47 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/zjps.2025.342882.1083 | ||
| Authors | ||
| Fatima Amer* 1; Ausama Jaccob2; Falah Hassan3 | ||
| 1Department of Basrah health ministry, health center of Basrah university | ||
| 2Department of pharmacology and toxicology, University of Basrah | ||
| 3Department of Clinical Laboratory Sciences, College of Pharmacy, Almaaqal University, Basrah, Iraq | ||
| Abstract | ||
| Abstract Background: Passive smoking causes an annual death rate, making tobacco use a serious health concern. Chronic smoking is a social risk factor for bone illnesses such as osteo-malacia, diabetic osteopathy, and Paget's disease because it deteriorates muscle function and bone density. The predominant causes for these disorders are a deficiency of osteoblasts in producing bone cells or an increased rate of bone resorption by osteoclasts. Nonetheless, the precise chemicals in cigarette smoke that induce these alterations remain unidentified. Researchers have examined the mechanism of bone turnover in metabolic bone diseases using bone turnover biomarkers and bone density ratio. Research indicates that cigarette smoke alters fracture hematoma development impedes the healing process, and influences the action of cytokines and growth factors at the fracture location. Conclusion: Quitting smoking is essential for decreasing the prevalence of skeletal problems and assessing smokers' potential for osteoporosis and fractures. Additional study is required to assess smokers' risk and design an approved pharmacological treatment. | ||
| Keywords | ||
| Keywords: Smoking; osteoporosis; fracture healing | ||
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