Assessment of thrombosis risk and antibody response against SARS-Cov-2 vaccination among health care workers in TBRI, Egypt | ||
| Microbes and Infectious Diseases | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 July 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2025.393119.2880 | ||
| Authors | ||
| Doaa Mamdouh Aly* 1; Bothaina Madkour2; Hala Badawi3; Nihal M El Assaly1; Wafaa A. Kandeel4; Ashraf Abdelkhalik5; Manal Youssef Zahran1; Omar Sayyouh6; Hesham A. Elmeligy7; Samia H El-Shishtawy8 | ||
| 1Clinical Chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt | ||
| 2Haematology Department, Theodor Bilharz Research Institute, Giza, Egypt | ||
| 3Medical Microbiology and Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt | ||
| 4Biological Anthropology Department, Medical Research and Clinical Studies Institute, National Research Centre, Egypt | ||
| 5Intensive Care Department, Theodor Bilharz Research Institute, Giza, Egypt | ||
| 6Infection Prevention and Control Unit, Theodor Bilharz Research Institute, Giza, Egypt | ||
| 7General Surgery Department- Theodor Bilharz Research Institute, Giza, Egypt | ||
| 8Nephrology Department, Theodor Bilharz Research Institute, Giza, Egypt | ||
| Abstract | ||
| Background: The emergence of COVID-19 pandemic urged the scientific community to develop vaccines to combat the virus spread. We tried to investigate the clinical and antibody response to SARS-Cov-2 across different types of vaccines among a group of healthcare workers at an Egyptian medical institute. Methods: This cohort study comprised 221 healthcare workers in an Egyptian medical institute, divided into 4 groups according to the type of vaccine given: AstraZeneca, Sinovac, Pfizer, and Moderna. Measurement of the Anti-Receptor-Binding Domain Ig M and Ig G by EIA COVID-19 RBD Ig M and IgG Test Line Clinical Diagnostics kit was done for all study participants to assess the immune response in each vaccinated group. Also the thrombosis risk was evaluated by the measurement of platelets and D-dimer. Results: AstraZeneca-vaccinated healthcare workers had lower values of platelet count after the vaccination (p< 0.001). D-dimer levels in the AstraZeneca-vaccinated healthcare workers group after the vaccination were higher as compared to baseline D-dimer levels (p< 0.001). We found that the IgG levels in AstraZeneca-vaccinated healthcare workers were the highest as compared to other types of vaccines (p= 0.018). The Ig G levels after the 1st dose of vaccination were significantly elevated in AstraZeneca-vaccinated healthcare workers when compared to Sinovac, Pfizer, and Moderna vaccines (p= 0.001, p= 0.017 respectively). Conclusion: The immune response against COVID-19 was significantly stronger in AstraZeneca vaccinated healthcare workers as compared to other types of vaccines. | ||
| Keywords | ||
| D-dimer; AstraZeneca; platelet | ||
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