Possible Prognostic ECG Indices for Cardiac Injury Associated with Experimentally Induced Chronic Doxorubicin-Cardiomyopathy in Dogs | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 02 July 2025 PDF (762.1 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.361309.2656 | ||
| Authors | ||
| Samar Elsharkawy* 1; Ahmed Saker2; Mohamed Naser2; Noha Bedeer2; Asmaa Saleh2; Besheer Elshafey2 | ||
| 1Department of Surgery, Anaesthesiology, and Radiology, Faculty of Veterinary Medicine, Cairo University. | ||
| 2Department of Internal Medicine, Faculty of Veterinary Medicine, Damanhur University, Beheira | ||
| Abstract | ||
| Doxorubicin (DOX) induced- cardiomyopathy is a predictable outcome for doxorubicin administration in dogs treated for various malignancies. Early detection of cardiac alterations is a mandatory step to prevent permanent and irreversible cardiac damage. Many tools have been employed to detect those alterations including echocardiography (ECHO), electrocardiography (ECG) and cardiac biomarkers analysis. ECG is a cost-effective tool used to scan for DOX induced- cardiomyopathy in dogs. To this point, no detection criteria has been established for chronic DOX- cardiotoxicity in dogs using ECG. Five adult healthy male dogs were employed to receive six consecutive doses of DOX (30 mg/ m2) which was repeated with three-weeks interval. Baseline physical, ECHO, ECG and serum biochemical examinations were conducted before the first DOX application. Serial ECG evaluation was carried out just prior to the next DOX session then three weeks after discontinuing DOX therapy. Lead II of the ECG was standardized for all measurements including heart rate, rhythm, duration and amplitude of the P wave and QRS complex, duration of the PR, QT and QTc intervals, existence and amplitude of the J wave, polarity and amplitude of the T wave, mean electrical axis and the position of the ST segment. No cardiac arrhythmias were detected except for sinus tachycardia. The most detected ECG alterations were ST depression or/ elevation, T wave flattening and inversion as well as prominent J wave. In conclusion, ST interval and T wave changes along with prominent J wave could represent important indicators for chronic DOX-cardiomyopathy in dogs. | ||
| Keywords | ||
| Cardiomyopathy; Dogs; Doxorubicin; Electrocardiography | ||
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