Evaluation of Methyl Transferase-like 3 (METTL3) expression in Pancreatic Adenocarcinoma: an immunohistochemical study | ||
| Benha Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 04 July 2025 PDF (1.27 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2025.363085.2333 | ||
| Authors | ||
| Marwa S Abd Allah1; Abd Ellatif M Elbalshy2; Shrook S Abdallah* 3; Aya H Abdelbary4; Eman I Elgendy5 | ||
| 1Department of Pathology, Faculty of Medicine-Benha University | ||
| 2Department of pathology, Faculty of Medicine, Benha University | ||
| 3(M.B.B.CH), Demonstrator of Pathology, Faculty of Medicine-Benha University | ||
| 4Department of Pathology, National Liver Institute Menoufia University | ||
| 5Department of Pathology, Faculty of Medicine- Benha University | ||
| Abstract | ||
| Background: Pancreatic carcinoma is the 12th most common cancer worldwide. Pancreatic cancer is one of the leading causes of cancer death worldwide. Aim: Evaluation Of the role of Methyltransferase like 3 (METTL3) expression by immunohistochemistry in pancreatic ductal adenocarcinoma and its relation with clinicopathological data. Material and methods: This retrospective study analyzed 50 cases of pancreatic ductal adenocarcinoma (PDAC) and 15 normal pancreatic tissue samples from Egyptian patients, collected between 2019 and 2023 using formalin-fixed paraffin-embedded (FFPE) samples. METTL3 proteins was assessed by Immunohistochemistry in these cases Results: METTL3 expression was negative in 26% of cases, low in 36%, and high in 38% of PDAC cases. A significant positive relationship was found between METTL3 expression and histologic grade, primary tumor extent, regional lymph node involvement, and pathological Tumor-Node-Metastasis (TNM) staging (p<0.05). Additionally, METTL3 expression showed significant negative correlation with tumor infiltrating lymphocytes. Conclusion: The study reveals that METTL3, an N6-methyladenosine RNA methyltransferase, is upregulated in pancreatic ductal adenocarcinoma (PDAC) tissues, correlated with tumor size, grade, and advanced staging, suggesting potential therapeutic target. | ||
| Keywords | ||
| Pancreatic carcinoma; PDAC; METTL3 | ||
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