Biochemical Indicators of Early Neurological Deterioration in Ischemic Stroke: A Hospital-Based Study. | ||||
| Zagazig University Medical Journal | ||||
| Volume 31, Issue 8, August 2025, Page 4120-4129 PDF (387.07 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2025.389314.3973 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Esraa Mohamed Abd Alrasheed  1; Mohammed Hanafy Aly Ghonemy2
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| 1Neurology department, faculty of medicine, zagazig university, sharqia, egypt | ||||
| 2Neurology department ,faculty of medicine ,Zagazig university,Zagazig ,egypt | ||||
| Abstract | ||||
| Title: Biochemical Indicators of Early Neurological Deterioration in Ischemic Stroke: A Hospital-Based Study. Abstract Background: Understanding the cause of early neurological decline (END) subsequent to a cerebrovascular stroke can help direct the early management techniques and produce better outcomes to identify biochemical predictors of early neurological decline in patients with cerebrovascular stroke. Methods: A study conducted in a hospital with a retrospective cohort; all cases obtained from hospital records from the period of (January 2023 -December 2024). Upon admission all patients underwent daily (seven days) assessments by using the Modified Rankin Scale (mRs) and the National Institutes of Health Stroke Scale (NIHSS) as well as biomarkers, and radiographic tests, Patients with and without END were separated into two groups. The statistical analysis was performed using IBM SPSS Statistics for Windows. Results: END affected 34% of the 300 patients. Patients with END were 69.44 ± 15.39 years old on average (p < 0.001). Males made up 52.5% of the non-END group and 52.9% of the END group (p = 0.946). From day 1 to day 7, END was significantly correlated with age, IHD, stroke history, and NIHSS. END and uric acid, HbA1c, total cholesterol, HDL, LDL, triglycerides, WBCs, platelets, LDH, ferritin, ESR, CRP, and fibrinogen were significantly different, according to biomarker analysis. Conclusion: Significant predictors of our findings revealed END in patients with acute ischemic stroke could help with early END diagnosis and enhance patient outcomes. Keywords: Early Neurological Deterioration, Ischemic stroke, NIHSS, Biochemical indicators. | ||||
| Keywords | ||||
| Early Neurological Deterioration; Ischemic stroke; NIHSS; Biochemical indicators | ||||
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