Can FDG-PET-CT Predict L.N. Capsular Invasion in Metastatic Nodes in Patients with Locoregional Recurrent Differentiated Thyroid Cancer?. | ||||
| Ain Shams Journal of Surgery | ||||
| Volume 18, Issue 3, July 2025, Page 229-237 PDF (320.69 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asjs.2025.387515.1204 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Ahmed Mohamed Amer* ; Sharif Ahmed Abdelkarim; Hossam Mohamed Farid | ||||
| Department of Surgical Oncology, National Cancer Institute, Faculty of Medicine, Cairo University, Egypt | ||||
| Abstract | ||||
| Introduction: To assess the ability of (PET-CT to detect L.N. affection with tumor in differentiated thyroid cancer, and to assess L.N. capsular invasion which may be an important factor for subsequent locoregional tumor recurrence. Ain of work: The 2015 American Thyroid Association (ATA) guidelines state that 18 F-FDG PET-CT is highly advised for the evaluation of therapy response, the identification of lesions in metastatic disease, and outcome prediction in high-risk patients who have elevated thyroglobulin levels and negative whole-body iodine scans (I131). It is not advised as a standard pre-operative scan or for the assessment of thyroid nodules.21 Patients and methods: cross-sectional study included patients admitted to National cancer institute with recurrent well differtiated thyroid cancer (WDTC) aged between 35 and 70 years. The patients were diagnosed by elevated thyroglobulin (Tg) level, neck U.S., or C.T. Then FDG- PET CT was performed to assess regional recurrence and level of SUV nodal activity. Resection of recurrence was performed, and pathological results were obtained. Results: in the 15 patients who did PET- CT it was able to detect nodal metastasis in all of the 15 patients, with all of them had pathologically proven nodal metastasis. 11 patients out of the 15showed nodal activity of 10 SUV or more, with three of them showed nodal activity of 10 or more in their second nodal metastasis. All patients with nodal activity of 10 SUV or more showed L.N.s capsular invasion with the tumor. Conclusion: 18- FDG- PET CT may be an important tool for detection of locoregional WDTC recurrence, the diagnose of L. Ns affection and infiltration nodal capsule. It seemed that SUV activity was related more to tumor biology, activity, and the presence of tumor infiltration of L.N capsule. It seemed that SUV activity of 10 or more may be indicator of L.N. capsular invasion, and hence correlated with more incidence of recurrence. | ||||
| Keywords | ||||
| Well differentiated thyroid cancer; diagnose; FDG-PET CT | ||||
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