Prevalence of Proteus mirabilis isolated from urinary tract infections among children in Diyala Governorate | ||
| International Journal of Health Sciences (Egypt) | ||
| Articles in Press, Accepted Manuscript, Available Online from 05 July 2025 PDF (829.92 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijhegy.2025.399514.1067 | ||
| Authors | ||
| Hanan Raheem Hassooni* ; Enas Ammar Mohammed; Wissam F. Hassan; Adil Hassan Alhusseiny | ||
| Department of Internal Medicine, College of Medicine, University of Diyala, Diyala, Iraq | ||
| Abstract | ||
| Background: Urinary tract infection (UTI) is a bacterial infection of the bladder and associated structures. These are patients with no structural abnormality and no comorbidities, such as diabetes, immunocompromised, or pregnant. Uncomplicated UTI is also known as cystitis or lower UTI. Aim of study: Isolate and determine the prevalence of Proteus mirabilis in children with urinary tract infections (UTIs) and their susceptibility to common antibiotics. Methods: This study was conducted at Al-Batoul Teaching Hospital for Maternity and Children, from May 2023 to March 2024. A total of 280 urine samples were collected according to high-precision standards, ensuring that no antibiotics were taken prior to collection. All samples were cultured on blood agar and MacConkey agar, then incubated at 37°C for 24 hours. Bacteria were identified and susceptibility tested using the Vitek system. Results: Twenty-one isolates were obtained out of 280, representing a percentage of 7.5%. The prevalence of bacterial infection was higher among females (80.9%), while it was 19% among males. P.mirabilis also showed high resistance to penicillin group (penicillin, piperacillin and amoxicillin-clavulanic acid) at rates of 90.4%, 76.1% and 57.1%, respectively. and Cephalosporin group (Cefepime, Cephotoxime, Cefoxitin, and Ceflazidime) at rates of 76.1%, 71.4%, 66.6%, and 76.1%, respectively. The results also showed slight resistance to fluoroquinolones group (gentamicin, ciprofloxacin, and levofloxacin) with rates of 28.5%, 33.3%, and 4.7%, respectively. However, the results of our study showed the bacteria were sensitive to carbapenems group (meropenem and imipenem) was 95.2% and 80.9%, respectively. And in amikacin was 85.7% within the aminoglycosides group. Conclusion: The best treatment for urinary tract infections caused by Proteus mirabilis is meropenem, followed by amikacin, and then imipenem. | ||
| Keywords | ||
| UTI; Paediatric urinary tract infections; Proteus mirabilis; Antibiotic resistance; cystitis | ||
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