Prevalence of Diabetic Nephropathy in Type 1 Diabetics at University Hospital Center of Sidi Bel-Abbes. | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Articles in Press, Accepted Manuscript, Available Online from 06 July 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2025.371226.2490 | ||||
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| Authors | ||||
Mounia SAKOUHI1; Derouicha MATMOUR  2; Bouziene BOUMESJED3; Houria MEHAREB4; Leila HOUTI4; Dalila MIRAOUI 4; Aissa BOUDIBA4
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| 1University of Sidi Bel-Abbes, 22000, Algeria. | ||||
| 2pharmacy departement, medecine faculty of Sidi bel-abbes, Algeria | ||||
| 3Department of Pharmacy, University of Sidi Bel-Abbes, 22000, Algeria. | ||||
| 4Cité 125 Logements, Guembetta, Sidi Bel-Abbès, 22000 Algeria | ||||
| Abstract | ||||
| Introduction: Diabetic nephropathy (DN) is a major microvascular complication of diabetes. It affects 30% of the world population of T1D. DN is a serious complication and is responsible for significant morbidity. The objective of this study was to determine the prevalence of this complication in T1D patients consulting at the department of diabetology-endocrinology and metabolic diseases of the university hospital center (UHC) of Sidi Bel-abbes, Algeria. Materials and Methods: This was a descriptive cross-sectional study of DN in T1D patients of Sidi Bel-abbes UHC. It was carried out over a period of eight years, from January 1, 2012 to December 31, 2020, involving 341 T1D patients. The judgment criteria were: positive microalbuminuria, positive macroalbuminuria and IRCT estimated by a GFR below 60 mL/min/1.73 m2. The data were collected from files using a questionnaire and analyzed by the SPSS software, version 20. Results: 341 T1D patients were included, sex ratio M/F equal to 0.99. The mean creatinine was 9.23 ± 4.93 mg/L (5.13 to 48 mg/L). Renal function was impaired in 44 (12.90%). As for glomerular filtration rate (GFR), 97 (28.5%) T1D patients had a GFR less than 60 mL/min/1.73 m². 33 (9.6%) T1D patients had microalbuminuria, 51 (15%) had macroalbuminuria and 06 (1.8%) patients had hyperuricemia. The prevalence of chronic kidney disease (CKD) was 12.9% and that of DN)was 24.60%. Conclusion: DN is one of the most harmful complications of T1D that leads to renal failure. This study showed that 24.6% of the cases studied developed DN. | ||||
| Keywords | ||||
| Diabetic nephropathy; Type 1 diabetes; microalbuminuria; macroalbuminuria; end-stage chronic renal failure | ||||
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