ANTI-INFLAMMATORY PROPERTIES OF CAPSICUM EXTRACT FROM ALGERIAN RED CHILI PEPPER: EVALUATION AND FORMULATION OF A TOPICAL PREPARATION | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Articles in Press, Accepted Manuscript, Available Online from 06 July 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2025.382144.2545 | ||
| Authors | ||
| Saida TOUZOUIRT* 1; Foudil RAHAL2; Ouiza ABDELLAOUI2; Lylia AITBRAHAM2; Hana BENOUATTAS3; Henni CHADER3; Abdelhamid ABDENNOURI4 | ||
| 1Department of Process Engineering, Faculty of Technologies, M'Hamed Bougara University, Boumerdes, Algeria | ||
| 2Department of Chemistry, Faculty of Science, Mouloud Mammeri University, Tizi-Ouzou, Algeria | ||
| 3National Laboratory for the Control of Pharmaceutical Products (LNCPP), Algiers, Algeria | ||
| 4Department of Pharmacy, Faculty of Medicine, Mouloud Mammeri University, Tizi-Ouzou, Algeria | ||
| Abstract | ||
| Capsaicin is a natural compound with anti-inflammatory and analgesic properties. effective in conditions like rheumatoid arthritis when administered orally or topically. Despite Algeria being the world’s ninth-largest chili producer in 2012, its therapeutic potential remains underexplored. This study investigates the anti-inflammatory activity of an ethanol extract from Capsicum annuum fruits cultivated in Algeria and assess the efficacy of a corresponding topical ointment in a mouse ear edema model. The extract, rich in capsaicin and β-carotene, was obtained via Soxhlet extraction using 96% ethanol. UV–visible spectrophotometry and HPLC confirmed the presence of capsaicin and dihydrocapsaicin in an approximate 4:3 peak area ratio. Anti-inflammatory activity was assessed using a mouse ear edema model induced by xylene. The results of this study demonstrate that Capsicum extract exhibits significant anti-inflammatory activity. A 0.13 g/mL concentration of the Capsicum extract reduced edema weight by 75.13%. Furthermore, a topical ointment formulated with the extract produced an 85% reduction in edema. These results suggest that Capsicum annuum extract exhibits potent anti-inflammatory effects and holds promise for topical therapeutic applications | ||
| Keywords | ||
| Capsicum annuum; anti-inflammatory activity; topical ointment; Capsicum extract; Algerian chili pepper | ||
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