Is Hypothyroidism a Hidden Culprit of Short Stature in Inflammatory Bowel Disease and Celiac Disease? | ||
| Pediatric Sciences Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 06 July 2025 PDF (709.28 K) | ||
| Document Type: Original Research | ||
| DOI: 10.21608/cupsj.2025.387742.1164 | ||
| Authors | ||
| Shimaa Atef1; Nabil Mohsen1; Mahmoud Morsy Alhamamsy2; Mai Ali3; Sara Tarek* 1 | ||
| 1Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt | ||
| 2Department of Pediatrics, Fawzy Moaz Pediatric Hospital, Alexandria, Egypt | ||
| 3Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt | ||
| Abstract | ||
| Background: Inflammatory bowel disease (IBD) and celiac disease are characterized by chronic intestinal inflammation, and extra-intestinal manifestations. Aim of the work: To assess if hypothyroidism is a contributing factor in short stature in children with IBD and celiac disease. Subjects and Methods: This cross-sectional study included 150 children divided into three groups (50 in each group). Group A included those with confirmed IBD and group B with confirmed celiac disease. Group C included healthy children as a control group. All children underwent detailed anthropometric measurements, and ELISA test for TSH, free T4, and free T3 levels. Results: The IBD group mean ± SD (median, range) age was 7.68 ± 3.27 (7.34, 1.69 – 14.46) years, 19 (38%) were females and 31(62%) were males. The celiac disease group mean ± SD (median, range) age was 9.42 ± 3.79 (7.55, 1.52 – 15.36) years, 25 (50%) were females and 25 (50%) were males, compared to the control group mean ± SD (median, range) age of 9.88 ± 3.25 (9.58, 3.49 – 16.53) years, 29 (58%) were females and 21 (42%) were males (p= 0.04, p= 0.095 respectively). The mean ± SD (median, range) of disease duration of IBD was 4.06 ± 2.1 (2.85, 1.6-9.2) years, while the mean ± SD (median, range) of disease duration of celiac disease was 4.39 ± 2.4 (4-, 1.55-12.5) years (p=0.5). The mean ± SD (median, range) weight Z score of IBD group was -0.42 ± 1.53 (-0.65, -4.24 – 2.42), and height Z score was -1.08 ± 1.6 (0.98, -3.64 –1.47), while the mean ± SD (median, range) weight Z score of celiac disease group was -0.72 ± 1.44 (-0.85, -3.68 – 2.24), and height Z score was -1.57± 1.29 (-1.4, -4.58 – -0.76) compared to the mean ± SD (median, range) weight Z score of the control group of -0.28 ± 0.89 (-0.29 , -1.6 – 1.87) , and height Z score was -0.53 ± 1.02 (-0.54-, -1.77–1.32) (p =0.008, p=0.000 respectively). Short stature (height Z score< -2 SD), was present in 17 (34%) of patients in celiac group, 13 (26%) of patients in IBD group and none of the control group (p=0.001). All had normal T3, T4 and TSH levels. Conclusion: Short stature is common among children with IBD and celiac disease. Hypothyroidism is not a main cause of short stature in IBD and celiac disease, other contributing factors to short stature in IBD and celiac disease should be searched for. | ||
| Keywords | ||
| Growth failure; Ulcerative colitis; Crohn's disease; Celiac disease; Thyroid dysfunction | ||
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