Behavioral Psychomotor Performance, Thyroid Functional and Structural Changes with Glucagon-Like Peptide-1 Receptor Agonists in Rats | ||
| Suez Canal University Medical Journal | ||
| Article 5, Volume 27, Issue 6, June 2024, Pages 46-57 PDF (589.8 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scumj.2024.438080 | ||
| Authors | ||
| Dalia Ibrahim Ahmed* 1; Nadia Abo Zied Ahmed2; Dina A. Ali2; Mohamed Kamal3; Eman Kolieb1 | ||
| 1Department of Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||
| 2Department of Clinical Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||
| 3Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||
| Abstract | ||
| Background: Liraglutide, a glucagon-like peptide-1(GLP-1) receptor agonist, is used to treat patients with type-2 diabetes mellitus. It may have several adverse effects on thyroid glands as GLP-1 receptors are highly expressed in thyroid glands. Aim of Study: To investigate the effect of (liraglutide) on structure and function of thyroid gland in rats and its effect on behavioral and psychomotor function. Material and Methods: This study was carried out in the animal house, Faculty of Medicine, Suez Canal University. Rats were divided randomly into 3 groups, 6 rats/group. Control group: rats received normal saline once daily, GLP -short term and GLP -long term groups: rats received (0.075 mg/kg/day) liraglutide intraperitoneally (i.p.) once daily for 11 days and 12 weeks respectively. Anxiety was assessed using open field test and forced swimming test for depressive-like behavior. Estimation of TSH, FT3, FT4 and calcitonin in addition to histopathological and immunohistochemical changes for calcitonin expression in thyroid tissue as a clinical biomarker for C-cell diseases were done. Results: Anxiety-like behaviors were significantly increased in GLP -long term group. Forced swimming showed longer immobility time in the GLP -long term group. Reduced TSH, elevated calcitonin in GLP -long term group. FT4 and FT3 were insignificantly elevated. Histopathological changes were noticed and immunohistochemical expression of calcitonin significantly increased in thyroid tissue of GLP -long term group. Conclusion: There is a probable high risk of thyroid hyperplasia and cancer in GLP -long term treatment. | ||
| Keywords | ||
| Glucagon-Like Peptide; thyroid hyperplasia; calcitonin | ||
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