Serum ceramides association with cardiovascular and chronic kidney diseases in type 2 diabetes | ||||
| Medicine Updates | ||||
| Articles in Press, Accepted Manuscript, Available Online from 07 July 2025 PDF (679.17 K) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/muj.2025.391625.1231 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Asmaa Galal EL-shahat  1; Mamdouh Radwan El-nahas2; Maivel H. Ghattas3; Sara Mohamed Osama2
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| 1Department of internal medicine Faculty of Medicine, Port Said University | ||||
| 2Department of Internal Medicine, Faculty of Medicine, Port Said University | ||||
| 3Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Port Said University | ||||
| Abstract | ||||
| Diabetes mellitus (DM) is a systemic metabolic condition that affects 463 million adults globally. It is the leading cause of peripheral neuropathy, nephropathy, cardiovascular disease, blindness, and amputation. Although the pathophysiology and pathogenesis of diabetes mellitus and its complications have long been linked to lipids, new research has identified the ceramides class of bioactive sphingolipids with cell signaling and second messenger properties as being especially significant contributors to insulin resistance and the underlying mechanisms of DM complications.. There is growing evidence that several ceramide species mediate cellular pathways implicated in the development and progression of microvascular and macrovascular problems of diabetes mellitus, in addition to their relationship with insulin resistance and the pathophysiology of type 2 diabetes. Recent Research on ceramide species as possible new therapeutic targets and biomarkers is made possible by developments According to the latest studies, increased levels of particular circulating ceramides and their ratios are linked to the development of cardiovascular disease (CVD) in the future. In people with chronic type 2 diabetes (T2D), we investigated the relationships between blood ceramide levels and cardiovascular disease (CVD), kidney disease, and all-cause mortality. | ||||
| Keywords | ||||
| Serum ceramide; cardiovascular disease; chronic kidney disease; kidney function; and Type 2 diabetes | ||||
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