Exploring the Antiviral Potential of Single Garlic Oil Against COVID-19: A Natural Remedy for Viral Infections
Elsheikh, W., El Hawary, S., Kutkat, O., Eldesoky, A., El-Raey, M., ashour, R., Fayed, M. (2025). Exploring the Antiviral Potential of Single Garlic Oil Against COVID-19: A Natural Remedy for Viral Infections. EKB Journal Management System, 68(10), 649-657. doi: 10.21608/ejchem.2025.369972.11495
walaa A Elsheikh; Seham El Hawary; omnia Kutkat; Ahmed Hamed Eldesoky; Mohamed A. El-Raey; Rehab ashour; Mohamed Fayed Fayed. "Exploring the Antiviral Potential of Single Garlic Oil Against COVID-19: A Natural Remedy for Viral Infections". EKB Journal Management System, 68, 10, 2025, 649-657. doi: 10.21608/ejchem.2025.369972.11495
Elsheikh, W., El Hawary, S., Kutkat, O., Eldesoky, A., El-Raey, M., ashour, R., Fayed, M. (2025). 'Exploring the Antiviral Potential of Single Garlic Oil Against COVID-19: A Natural Remedy for Viral Infections', EKB Journal Management System, 68(10), pp. 649-657. doi: 10.21608/ejchem.2025.369972.11495
Elsheikh, W., El Hawary, S., Kutkat, O., Eldesoky, A., El-Raey, M., ashour, R., Fayed, M. Exploring the Antiviral Potential of Single Garlic Oil Against COVID-19: A Natural Remedy for Viral Infections. EKB Journal Management System, 2025; 68(10): 649-657. doi: 10.21608/ejchem.2025.369972.11495

Exploring the Antiviral Potential of Single Garlic Oil Against COVID-19: A Natural Remedy for Viral Infections

Egyptian Journal of Chemistry
Volume 68, Issue 10, October 2025, Page 649-657  XML PDF (887.59 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2025.369972.11495
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Authors
walaa A Elsheikh email 1; Seham El Hawaryorcid 2; omnia Kutkatorcid 3; Ahmed Hamed Eldesokyorcid 4; Mohamed A. El-Raeyorcid 5; Rehab ashour6; Mohamed Fayed Fayedorcid 7
1Ministry of health and populations, Cairo, Egypt.
2Department of Pharmacognosy, Faculty of Pharmacy, Cairo University
3National Research Centre, Water pollution Department, Center of Scientific Excellence for Influenza Viruses, 33 El buhouth Street, P.O. Box 12622, Giza, Egypt.
4National Research Centre Pharmacognosy Natural Product Chemistry
5National Research centre
6Department of Pharmacognosy,Faculty of Pharmacy, Cairo University
7Pharmacology department, medical division, national research centre
Abstract
In recent decades, the incidence of viral pandemics has risen significantly. These pandemics not only result in millions of deaths but also hinder economic growth and development. The World Health Organization (WHO) declared COVID-19 a global health crisis in 2020. The disease is caused by the β-coronavirus, severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2). This study aimed to investigate the in-vitro anti-SARS-CoV-2 and in silico activities of volatile constituents from single clove garlic, as well as to identify these constituents using Gas Chromatography-Mass Spectrometry (GC/MS) analysis. A total of 27 compounds were identified. The major compounds detected were diallyl disulfide, allyl trisulfide, and 2-vinyl-1,3-dithi-4-ene. The in-vitro cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, and the 50% cytotoxic concentration (CC50) of the volatile constituents was established. Additionally, a geometry-based molecular docking approach (PatchDock) was employed to create docking modifications that result in favorable molecular shape complementarity.
Keywords
Single clove garlic; Volatile constituents; SARS CoV-2; IL-6; TNFα; Antiviral; Molecular docking
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