Extended Letrozole Regimen For Treatment Of Clomiphene Resistant PCO Patient | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2023, Issue 1, January 2023 | ||||
| DOI: 10.58675/2682-339X.2162 | ||||
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| Authors | ||||
| Yehia Wafa1; Fahd AbdelAl El-Omda2; Mohammed Atef Mohammed Kamaly2 | ||||
| 1Department of Obstetrics and Gynecology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt. | ||||
| 2Department of Obstetrics and Gynecology, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt. | ||||
| Abstract | ||||
| Background: About 1 in 15 women are affected by polycystic ovarian syndrome (PCOS), a complex endocrine condition with a variety of causes. Excessive androgen secretion or activity is the primary endocrine disturbance, and aberrant insulin activity is seen in a large proportion of women. Aim and objectives: To contrast the efficacy of a prolonged letrozole treatment for treating clomiphene-resistant PCOS to that of a short letrozole therapy and a placebo. Subjects and methods: This prospective, interventional, research was done at Qena university hospital, Obstetrics and Gynecology department. All cases were subdivided into three groups: Group (A): 40 patients took short letrozole, Short letrozole group. Group (B): 40 patients took long letrozole, Long letrozole group. Group(C): 40 patients took placebo, Placebo group. The research lasted anywhere from 6-12 months. Result: There is a significant distinction among the groups regarding endometrial thickness with hCG trigger injection. Ovulation incidence was substantially greater in group B contrasted with group A contrasted with group C. Pregnancy incidence was substantially higher in group B contrasted with group A contrasted with group C. Conclusion: More and larger mature follicles, Elevated endometrial thickness & the number of pregnancies can be achieved with prolonged letrozole medication contrasted with shorter letrozole medication. | ||||
| Keywords | ||||
| polycystic ovary syndrome (PCOS); Letrozole regimen; Clomiphene | ||||
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